ArticleGenes2026
Genomic Insights into the Giant Shank Phenotype of Dong Tao Chickens Reveal Candidate Loci Involved in Skeletal Growth and Development.
Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe Dong Tao (DT) chicken is a traditional Vietnamese breed characterized by extremely enlarged shanks, representing one of the most distinctive morphological traits observed in domestic chickens. Despite its economic and cultural importance, the genetic basis underlying this phenotype remains poorly understood. Therefore, this study aimed to identify genomic regions and candidate genes associated with the giant shank phenotype in DT chickens.
methodsA total of 87 chickens were analyzed, including 30 DT individuals displaying the giant shank phenotype and 57 control animals from the Ac, Choi, and Ho Vietnamese breeds. Genotype data were obtained from high-density 600K single-nucleotide polymorphism arrays and low-coverage whole-genome sequencing datasets. Genome-wide association study (GWAS) was performed using a linear mixed model, while genetic differentiation between DT and control populations was evaluated through F
resultsFour significant genomic regions were identified on chromosomes 2, 4, 5, and 7. These regions harbored several biologically relevant candidate genes, including
conclusionsThese findings provide novel insights into the genetic architecture underlying the giant shank phenotype in domestic chickens and establish a foundation for future studies aimed at identifying the causal variants and molecular mechanisms involved in giant shank development.
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