Evidence map›Paper›PMID 42650041›Full record

ArticleGenes2026

Graph-Based Multi-Omics Integration Reveals Prognostic Histone Modification Reader Genes and Candidate Drug Targets in Colorectal Cancer.

Xiangjun Cui, Sibo Xue, Peijun Jiang, Langlang Shi, Tianyang Tan, Yuhan Xu, Guoqing Liu, Hu Meng, Guojun Liu, Yongqiang Xing

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiangjun CuiSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou 014010, China.
Sibo XueSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou 014010, China.
Peijun JiangSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou 014010, China.
Langlang ShiSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou 014010, China.
Tianyang TanSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou 014010, China.
Yuhan XuSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou 014010, China.
Guoqing LiuSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou 014010, China.
Hu MengSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou 014010, China.
Guojun LiuSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou 014010, China.
Yongqiang XingSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou 014010, China.

Funding

National Natural Science Foundation of China 62541205
6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) is driven by genetic alterations, epigenetic dysregulation and tumor microenvironment remodeling. Histone modification reader proteins serve as key epigenetic regulators of anti-tumor immunity, yet their synergistic immune networks, combined prognostic roles and immune subtype heterogeneity remain poorly understood.

methodsHere, we integrated multi-omics data and graph attention networks (GAT) to systematically screen prognostic-associated histone reader genes. We then conducted analyses using the immunoassay pipeline and ultimately identified hub immune-related genes validated in independent external cohorts. Additional analyses, including single-cell RNA sequencing (scRNA-seq), molecular docking and multiple in silico functional assays, were performed based on retrospective public datasets.

resultsFour core genes (

conclusionsThis work constructs an epigenetic immune regulatory network and a four-gene signature, offering promising biomarkers and actionable therapeutic targets for precision immunotherapy against CRC.

Indexed as

Biomarkers, TumorColorectal NeoplasmsHistone CodeEpigenesis, GeneticGene Expression Regulation, NeoplasticGene Regulatory NetworksHistonesHumansMultiomicsPrognosisTumor MicroenvironmentBiomarkers, TumorHistonescolorectal cancergraph attention networkhistone modification readerimmune microenvironmentmulti-omics

Identifiers

PMID42650041
PMCPMC13512344

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.