Evidence map›Paper›PMID 42650015›Full record

ArticleCancers2026

Nivolumab Plus Ipilimumab for Unresectable Hepatocellular Carcinoma in Early Real-World Clinical Practice: A Multicenter Analysis of Efficacy and Safety.

Hironao Okubo, Teppei Matsui, Makoto Chuma, Akihiro Funaoka, Haruki Uojima, Satoshi Narahara, Masahiro Kobayashi, Yuwa Ando, Tsunamasa Watanabe, Taito Fukushima and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Hironao OkuboDepartment of Gastroenterology, Juntendo University Nerima Hospital, 3-1-10 Takanodai, Nerima-Ku, Tokyo 177-8521, Japan.ORCID 0009-0003-2656-0508
Teppei MatsuiDivision of Gastroenterology and Hepatology, Department of Internal Medicine (Omori), School of Medicine, Faculty of Medicine, Toho University, Omorinishi 6-11-1, Ota-Ku, Tokyo 143-8541, Japan.
Makoto ChumaDepartment of Gastroenterology, Yokohama Hodogaya Central Hospital, 43-1 Kamadai-Cho, Hodogaya-Ku, Yokohama-Shi 240-8585, Japan.
Akihiro FunaokaGastroenterological Center, Yokohama City University Medical Center, 4-57, Urafune-Cho, Minami-Ku, Yokohama-Shi 232-0024, Japan.
Haruki UojimaDepartment of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-Ku, Kumamoto 860-8556, Japan.ORCID 0000-0003-1719-1352
Satoshi NaraharaDepartment of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-Ku, Kumamoto 860-8556, Japan.ORCID 0000-0001-8647-9486
Masahiro KobayashiGastroenterology Medicine Center, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura-City 247-8533, Japan.
Yuwa AndoDepartment of Gastroenterology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, Kawasaki-Shi 216-8511, Japan.
Tsunamasa WatanabeDepartment of Gastroenterology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, Kawasaki-Shi 216-8511, Japan.
Taito FukushimaDepartment of Gastroenterology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-Ku, Yokohama-Shi 241-8515, Japan.ORCID 0000-0002-1345-5608
Satoshi KobayashiDepartment of Gastroenterology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-Ku, Yokohama-Shi 241-8515, Japan.ORCID 0000-0002-2535-6586
Katsuharu HiranoDepartment of Gastroenterology, Shonan Tobu General Hospital, 500 Nishikubo, Chigasaki-Shi 253-0083, Japan.
Kota TsuruyaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara-Shi 259-1193, Japan.ORCID 0000-0002-9884-8039
Tatehiro KagawaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara-Shi 259-1193, Japan.ORCID 0000-0002-3442-1423
Shuichiro IwasakiDepartment of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-Ku, Sagamihara-Shi 252-0375, Japan.
Hisashi HidakaDepartment of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-Ku, Sagamihara-Shi 252-0375, Japan.ORCID 0000-0002-4151-5663
Hidenari NagaiDivision of Gastroenterology and Hepatology, Department of Internal Medicine (Omori), School of Medicine, Faculty of Medicine, Toho University, Omorinishi 6-11-1, Ota-Ku, Tokyo 143-8541, Japan.
Yasuhito TanakaDepartment of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-Ku, Kumamoto 860-8556, Japan.ORCID 0000-0002-2473-6966
Shin MaedaDepartment of Gastroenterology, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-Ku, Yokohama-Shi 236-004, Japan.ORCID 0000-0002-0246-1594
Manabu MorimotoGastroenterological Center, Yokohama City University Medical Center, 4-57, Urafune-Cho, Minami-Ku, Yokohama-Shi 232-0024, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

anti-programmed cell death 1CRAFITY scorecytotoxic T-lymphocyte-associated protein 4immune-related adverse eventimmunotherapy selectionresponse rate

Identifiers

PMID42650015
PMCPMC13510368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.