ArticleCancers2026
Reproducibility and Potential Prognostic Value of Spatial Metabolic PET Metrics in Oral Tongue Squamous Cell Carcinoma.
Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
BACKGROUND/
objectivesConventional FDG PET parameters quantify metabolic intensity and volume but not the location of the metabolic hotspot, whose peripheral shift may reflect aggressiveness. In surgically treated oral tongue cancer (OTC), we evaluated two spatial PET metrics-the normalised distance from the hotspot to the tumour centroid (NHOCmax) and perimeter (NHOPmax)-in two parallel analyses: prognosis and measurement reproducibility.
methodsWe retrospectively analysed 89 patients with preoperative FDG PET/CT. NHOCmax and NHOPmax were derived alongside conventional PET parameters. Associations with disease-free (DFS) and overall survival (OS) were assessed by uni and multivariable Cox models, and reproducibility was assessed across segmentation methods and by intra-reader repeatability.
resultsOver a median 83.4/102.1-month follow-up (DFS/OS), 29 DFS and 25 OS events occurred. In the prognostic analysis, higher NHOCmax (OS HR 1.14,
conclusionsNHOCmax and NHOPmax were associated with poorer survival, though not independently of stage and metabolic tumour volume, and were reproducible except in low-volume tumours; they warrant validation in larger cohorts.
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