Evidence map›Paper›PMID 42649942›Full record

ArticleCancers2026

Caleb Nathaniel Seavey, Kei Kawashima, Asama Khan, Élise Di Lena, Kazuaki Takabe, Mashaal Dhir

Abstract read
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Caleb Nathaniel SeaveyDepartment of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.
Kei KawashimaDepartment of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.ORCID 0000-0003-2503-9350
Asama KhanDepartment of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.ORCID 0009-0003-9174-4311
Élise Di LenaDepartment of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.
Kazuaki TakabeDepartment of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.ORCID 0000-0002-6435-4241
Mashaal DhirDepartment of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.ORCID 0000-0002-1426-1098

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI CANDACE S JOHNSON · 1985 to 2026
$116.6M
Impact of Circulating Myeloid Cell Clusters on Anti-Tumor ImmunityR01CA250412 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI ABRAMS, SCOTT I., EVANS, SHARON S · 2021 to 2025
$3.4M
Dissecting Molecular Mechanisms of Tumor-Induced Myeloid-Mediated Immune Suppression in Triple-Negative Breast CancerR01CA287731 · NCI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI Scott I. Abrams, Jianmin Zhang · 2024 to 2026
$2.8M
Leveraging the GTP Biosynthetic Pathway for Anti-Tumor TherapiesR37CA248018 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Anna Bianchi-Smiraglia · 2021 to 2026
$2.3M
Stress-induced immunosuppression via downregulation of interferon in triple negative breast cancerK08CA279766 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Shipra Gandhi · 2024 to 2026
$915k
Identifying the role of interferon and interferon-regulated chemokines in stress-induced immunosuppression in triple negative breast cancerR03TR004607 · NCATS · ROSWELL PARK CANCER INSTITUTE CORP · PI GANDHI, SHIPRA · 2023 to 2023
$174k
NCATS NIH HHS R03 TR004607NCI NIH HHS K08 CA279766NCI NIH HHS P30 CA016056NCI NIH HHS R01 CA250412NCI NIH HHS R01 CA287731NCI NIH HHS R37 CA248018
6 · The paper itself

Abstract

BACKGROUND/

objectivesKi67 is a well-established histologic proliferation marker across many cancers; however, its clinical application in pancreatic ductal adenocarcinoma (PDAC) has remained limited. Multiple studies have demonstrated that Ki67 is prognostic in PDAC, with higher Ki67 expression associated with worsened outcomes. In this study, we aimed to characterize the underlying biology of Ki67-enriched tumors.

methodsClinical and transcriptional data from PDAC patients were obtained from The Cancer Genome Atlas (TCGA) and three Gene Expression Omnibus (GEO) datasets. Mutational analysis from the TCGA cohort was also performed. Patients within each study were stratified into low- and high-expression groups based on the median transcript levels. Each dataset was analyzed independently, and differences between groups were subsequently compared across studies.

resultsConsistent with their enhanced proliferative capacity,

conclusions

Indexed as

Ki67MKI67pancreatic adenocarcinoma

Identifiers

PMID42649942
PMCPMC13510446

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.