ArticleCancers2026
DNA Polymerase Beta Catalytic and Fidelity Mutations Drive Platinum-Specific Drug Sensitivity.
Jacob Lindquist, Josh Heyza, Istri Ndoja, Nasrin Movahhedin, Chris Yunker, Marina Cardo-Vila, Seongho Kim, Joann Sweasy, Steve M Patrick
Abstract read
In one paragraphArticle in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Jacob LindquistDepartment of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI 48201, USA.
Josh HeyzaDepartment of Pharmacology, Institute of Environmental Health Sciences, Wayne State University and Karmanos Cancer Institute, Detroit, MI 48201, USA.ORCID 0000-0003-0847-0501 Istri NdojaDepartment of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI 48201, USA.ORCID 0000-0003-1005-1146 Nasrin MovahhedinDepartment of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI 48201, USA.
Chris YunkerDepartment of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI 48201, USA.
Marina Cardo-VilaDepartment of Otolaryngology, University of Arizona, Tuscon, AZ 85724, USA.
Seongho KimDepartment of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI 48201, USA.ORCID 0000-0003-1120-073X Joann SweasyEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Steve M PatrickDepartment of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI 48201, USA.ORCID 0000-0003-3325-6750 Funding
Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Julie Lynn Boerner · 1985 to 2026
$68.4MTRAINING PROGRAM IN THE BIOLOGY OF CANCERT32CA009531 · NCI · WAYNE STATE UNIVERSITY · PI Larry H Matherly · 1985 to 2026
$5.3MNovel role of APOBEC3 enzymes as key mediators of cisplatin sensitivity through aberrant processing of interstrand crosslinksR01CA229535 · NCI · WAYNE STATE UNIVERSITY · PI PATRICK, STEVE M · 2019 to 2024
$2.0MMolecular regulation of double-strand break repair by MDC1R00GM149942 · NIGMS · WAYNE STATE UNIVERSITY · PI Joshua Heyza · 2025 to 2026
$498kNCI NIH HHS P30 CA022453NCI NIH HHS P30CA022453NCI NIH HHS R01 CA229535NCI NIH HHS R01CA229535-01NCI NIH HHS T32 CA009531NCI NIH HHS T32CA009531NIGMS NIH HHS R00 GM149942
6 · The paper itselfAbstract
PubMed holds no abstract for this paper.
Indexed as
base excision repair (BER)cisplatinDNA polymerase β (Polβ)DNA repairinterstrand crosslinksnucleotide excision repair (NER)
Identifiers
PMID42649846
PMCPMC13511097
What OpenQuestion holds
Textmetadata
Read underepoch 390