Evidence map›Paper›PMID 42649777›Full record

ArticleBioengineering (Basel, Switzerland)2026

Apilarnil Improves Early Histological Repair and Biomechanical Strength During Experimental Femoral Fracture Healing in Rats.

Raşit Emin Dalaslan, Mehmet Arıcan, Meral Kekecoglu, Yalçın Turhan, Tuğçe Çaprazlı, Mehmet Gamsızkan, Zekeriya Okan Karaduman, Mücahid Osman Yücel, Sönmez Sağlam

Abstract read
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In one paragraph

Article in Bioengineering (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Raşit Emin DalaslanOrthopedics and Traumatology Department, Düzce University Medical Faculty, Düzce 81620, Turkey.ORCID 0000-0001-5068-8024
Mehmet ArıcanOrthopedics and Traumatology Department, Düzce University Medical Faculty, Düzce 81620, Turkey.ORCID 0000-0002-0649-2339
Meral KekecogluBeekeeping Research Development and Application Centre, Department of Biology, Faculty of Science, Düzce University, Düzce 81620, Turkey.
Yalçın TurhanOrthopedics and Traumatology Department, Health Sciences University, Bilkent City Hospital, Ankara 06800, Turkey.ORCID 0000-0002-1440-9566
Tuğçe ÇaprazlıBeekeeping Program, Düzce Vocational School, Düzce University, Düzce 81620, Turkey.
Mehmet GamsızkanDepartment of Pathology, School of Medicine, Düzce University, Düzce 81060, Turkey.
Zekeriya Okan KaradumanOrthopedics and Traumatology Department, Düzce University Medical Faculty, Düzce 81620, Turkey.ORCID 0000-0002-6719-3666
Mücahid Osman YücelOrthopedics and Traumatology Department, Düzce University Medical Faculty, Düzce 81620, Turkey.
Sönmez SağlamOrthopedics and Traumatology Department, Düzce University Medical Faculty, Düzce 81620, Turkey.ORCID 0000-0003-2651-8003

Funding

Düzce Üniversitesi 2020.04.02.1142
6 · The paper itself

Abstract

Fracture healing remains a major challenge in orthopedic practice, and natural bioactive products have attracted increasing interest as supportive agents for bone regeneration. Apilarnil (drone larvae homogenate), a bee-derived natural product with antioxidant and anti-inflammatory properties, has not previously been investigated in fracture healing. This study evaluated the effects of oral apilarnil on experimental femoral fracture healing in rats. Forty-two male Wistar Albino rats underwent standardized closed femoral fracture fixation with intramedullary Kirschner wire stabilization and were randomly assigned to either a control group or an apilarnil-treated group receiving 400 mg/kg/day orally. Animals were sacrificed on postoperative days 15, 30, and 45. Fracture healing was assessed radiologically using the Lane and Sandhu scoring system, histopathologically using the Huo scoring system, and biomechanically by a three-point bending test. Histopathological scores were significantly higher in the apilarnil group on postoperative day 15 (

Indexed as

apilarnilbiomechanicsbone regenerationfracture healinghistopathology

Identifiers

PMID42649777
PMCPMC13509693

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.