Complementary Activities of Bacteriophages and Antimicrobial Peptide Dendrimers Against Prosthetic Joint Infection Pathogens.

Shawna McCallin, Caroline Lanz, Sandra Jaccoud, Alexis E Laurent, Lee Ann Applegate, Philippe Abdel-Sayed

Abstract read

In one paragraph

Article in Bioengineering (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shawna McCallinRegenerative Therapy Unit, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland.

Caroline LanzRegenerative Therapy Unit, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland.

Sandra JaccoudRegenerative Therapy Unit, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland.

Alexis E LaurentManufacturing Department, Tec-Pharma SA, 1038 Bercher, Switzerland.ORCID 0000-0001-5738-8702

Lee Ann ApplegateRegenerative Therapy Unit, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland.ORCID 0000-0002-7346-9921

Philippe Abdel-SayedRegenerative Therapy Unit, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland.ORCID 0000-0002-6054-0573

Funding

Center for Applied Biotechnology and Molecular Medicine application round 02/2018Lausanne Orthopedic Research Foundation

6 · The paper itself

Abstract

Prosthetic joint infections (PJIs) remain a major challenge in orthopedic surgery due to the increasing prevalence of antimicrobial-resistant pathogens and their ability to form biofilms on implant surfaces. Local delivery of non-traditional antimicrobials through implant-associated biomaterials represents a promising strategy for preventing bacterial colonization while minimizing systemic antibiotic exposure. This study evaluated the antimicrobial activity and cytocompatibility of two bacteriophages (Phage K and Phage F1) and two antimicrobial peptide dendrimers (AMPDs; TNS18 and G3KL) against clinical isolates of

Indexed as

antimicrobial peptide dendrimersantimicrobial resistancebacteriophagesbiofilm-associated infectionsimplant coatingsorthopedic biomaterialsprosthetic joint infection

Identifiers

PMID42649760

DOI10.3390/bioengineering13080870

PMCPMC13510118

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.