Evidence map›Paper›PMID 42649742›Full record

ArticleBioengineering (Basel, Switzerland)2026

Quantitative Retinal Vascular Imaging Using Flood-Illuminated Adaptive Optics in Eyes with Lens Opacities.

Yash Porwal, Kenaan Elbash, Marlon Diaz, Emily Butler, Saige Oechsli, Laurence Magder, Andrew J Bower, Osamah Saeedi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yash PorwalDepartment of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, MD 21201, USA.
Kenaan ElbashDepartment of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, MD 21201, USA.
Marlon DiazDepartment of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, MD 21201, USA.
Emily ButlerDepartment of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, MD 21201, USA.
Saige OechsliDepartment of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, MD 21201, USA.
Laurence MagderDepartment of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, MD 21201, USA.
Andrew J BowerDepartment of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, MD 21201, USA.ORCID 0000-0003-1645-5950
Osamah SaeediDepartment of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, MD 21201, USA.ORCID 0000-0002-3082-4604

Funding

Direct Measures of Retinal Blood Flow and Autoregulation as Robust Biomarkers for Early GlaucomaR01EY031731 · NEI · UNIVERSITY OF MARYLAND BALTIMORE · PI SAEEDI, OSAMAH JAWAID · 2021 to 2025
$1.6M
Development, Refinement, and Validation of Sensitive and Robust AO-OCT Glaucoma BiomarkersR01EY038421 · NEI · UNIVERSITY OF MARYLAND BALTIMORE · PI Osamah Jawaid Saeedi · 2026 to 2026
$571k
Assessment of the Retinal Pigment Epithelial Cell Mosaic Based on Functional Imaging of Intracellular Pigment Dynamics in the Living Human EyeR00EY034550 · NEI · UNIVERSITY OF MARYLAND BALTIMORE · PI Andrew Bower · 2025 to 2026
$498k
NEI NIH HHS R00 EY034550NEI NIH HHS R00EY034550NEI NIH HHS R01 EY031731NEI NIH HHS R01 EY038421NIH HHS R01EY031731NIH HHS R01EY038421
6 · The paper itself

Abstract

Flood-illuminated adaptive optics (AO) imaging enables high-resolution quantification of retinal vascular morphology; however, its repeatability in older adults with lens opacities remains poorly characterized. In this prospective study, 40 subjects (66 eyes) underwent flood AO imaging using the rtx1 system (Imagine Eyes, Orsay, France) at three retinal locations across multiple sessions. Two independent masked graders measured lumen diameter (LD), total diameter (TD), wall cross-sectional area (WCSA), and wall-to-lumen ratio (WLR), with repeatability assessed using intraclass correlation coefficients (ICC). Inter-grader agreement was excellent for LD and TD across all regions (ICC range 0.974-0.994) and for WCSA at the superior and inferior regions (ICC range 0.902-0.952). Intrasession and intersession repeatability were similarly excellent for LD and TD across all locations. Repeatability remained excellent across age groups and cataract grades. Image region was the only variable significantly associated with image quality (

Indexed as

adaptive opticscataractexperiment reproducibilityflood illuminationlumen diameterretinal vasculaturevascular imagingvessel wall

Identifiers

PMID42649742
PMCPMC13509802

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.