Evidence map›Paper›PMID 42649437›Full record

ArticleBrain imaging and behavior2026

Assessing cognitive impairment in epilepsy using Arterial spin-labeled (ASL) perfusion imaging.

Qiuyan Chen, Jie Zhang, Rong Chen, Yameng Qin, Xu Wang, Qiang Liu, Zheng Yin, Ping Yang, Feng Rao, Longnan Wang and 4 more

Abstract read
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In one paragraph

Article in Brain imaging and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Qiuyan ChenClinical Medical College, Ningxia Medical University, Yinchuan, Ningxia Province, 750004, China.
Jie ZhangTao Yuan Community Service Center, Longhua District People's Hospital, Shenzhen, Guangdong Province, 518000, China.
Rong ChenDepartment of Neuroelectrophysiology, Cardiovascular and Cerebrovascular Disease Hospital Branch, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Province, 750004, China.
Yameng QinDepartment of Neurology, Heji Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi Province, 046000, China.
Xu WangClinical Medical College, Ningxia Medical University, Yinchuan, Ningxia Province, 750004, China.
Qiang LiuDepartment of Neurology, Ningxia Key Laboratory of Cerebrocranial Diseases, In- cubation Base of National Key Laboratory, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Province, 750004, China.
Zheng YinClinical Medical College, Ningxia Medical University, Yinchuan, Ningxia Province, 750004, China.
Ping YangClinical Medical College, Ningxia Medical University, Yinchuan, Ningxia Province, 750004, China.
Feng RaoClinical Medical College, Ningxia Medical University, Yinchuan, Ningxia Province, 750004, China.
Longnan WangClinical Medical College, Ningxia Medical University, Yinchuan, Ningxia Province, 750004, China.
Mengyun LiClinical Medical College, Ningxia Medical University, Yinchuan, Ningxia Province, 750004, China.
Yanzi JinDepartment of Neurology, Ningxia Key Laboratory of Cerebrocranial Diseases, In- cubation Base of National Key Laboratory, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Province, 750004, China.
Xianrui XuDepartment of Neurology, Ningxia Key Laboratory of Cerebrocranial Diseases, In- cubation Base of National Key Laboratory, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Province, 750004, China.
Qing ZhangDepartment of Neurology, Ningxia Key Laboratory of Cerebrocranial Diseases, In- cubation Base of National Key Laboratory, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Province, 750004, China. nxzhangqing@aliyun.com.

Funding

the Key Research and Development Program of Ningxia Province 2023BEG03010the National Natural Science Foundation of China 82060251the Ningxia Provincial Natural Science Foundations of China 2022- AAC03605the Ningxia Provincial Natural Science Foundations of China 2023AAC02062the Ningxia Provincial Natural Science Foundations of China 2023AAC03525
6 · The paper itself

Abstract

To investigate differences in cerebral blood flow (CBF) between people with epilepsy (PWE) who had cognitive impairment and those who did not, and to explore the association between cerebral perfusion abnormalities and cognitive dysfunction. A total of 89 patients who attended the epilepsy outpatient clinic of the Department of Neurology, General Hospital of Ningxia Medical University, between January 2021 and September 2025 were retrospectively included.Demographic and clinical data were collected. Cognitive function, sleep quality, anxiety, and depression were assessed using the Mini-Mental State Examination (MMSE), Pittsburgh Sleep Quality Index (PSQI), Self-Rating Anxiety Scale (SAS), and Self-Rating Depression Scale (SDS). Patients were classified into cognitive impairment and non-cognitive impairment groups according to their MMSE scores. CBF was assessed using a region-of-interest (ROI)-based approach, and intergroup differences in perfusion were analyzed. Compared with PWE without cognitive impairment,patients with cognitive impairment showed reduced cerebral perfusion in multiple brain regions.Specifically, significantly lower perfusion was observed in the bilateral insula, bilateral caudate nucleus, and left lentiform nucleus (all P< 0.05). Reduced cerebral perfusion in specific brain regions may be associated with cognitive impairment in PWE.

Indexed as

Cerebrovascular CirculationCognitive DysfunctionEpilepsyPerfusion ImagingAdultBrainFemaleHumansMaleMiddle AgedPerfusion Magnetic Resonance ImagingRetrospective StudiesSpin LabelsYoung AdultSpin LabelsCognitive impairmentEpilepsyEpileptic patientsThree-dimensional pseudo-continuous arterial spin labeling imaging

Identifiers

PMID42649437

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.