ArticleNature aging2026
Cytotoxic CD4
Abstract read
In one paragraph
Article in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
30 authors.
Enrique Gabandé-Rodríguez *Tissue and Organ Homeostasis Program, Cell-Cell Communication and Inflammation Unit, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Madrid, Spain. egabande@cbm.csic.es.ORCID http://orcid.org/0000-0002-9715-8714
Gonzalo Soto-Heredero *Tissue and Organ Homeostasis Program, Cell-Cell Communication and Inflammation Unit, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Madrid, Spain.ORCID http://orcid.org/0000-0001-8043-7314
Elisa CarrascoTissue and Organ Homeostasis Program, Cell-Cell Communication and Inflammation Unit, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Madrid, Spain.ORCID http://orcid.org/0000-0002-0817-1627
Carlos AnerillasTissue and Organ Homeostasis Program, Cell-Cell Communication and Inflammation Unit, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Madrid, Spain.ORCID http://orcid.org/0000-0003-4424-7913
José Ignacio Escrig-LarenaTissue and Organ Homeostasis Program, Cell-Cell Communication and Inflammation Unit, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Madrid, Spain.ORCID http://orcid.org/0000-0002-1538-8808
Jorge Martínez-CanoInteractions with the Environment Program, Immune System Development and function Unit, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Madrid, Spain.
Sandra Delgado-PulidoTissue and Organ Homeostasis Program, Cell-Cell Communication and Inflammation Unit, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Madrid, Spain.ORCID http://orcid.org/0000-0003-2055-6594
Isaac Francos-QuijornaTissue and Organ Homeostasis Program, Cell-Cell Communication and Inflammation Unit, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Madrid, Spain.ORCID http://orcid.org/0000-0002-3995-4499
Gabriela Desdín-MicóLaboratory of Regenerative Hematopoiesis, Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-8136-4145
Tatiana SmirnovaLaboratory of Regenerative Hematopoiesis, Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0009-0007-8002-9573
Manuel M Gómez de Las HerasTissue and Organ Homeostasis Program, Cell-Cell Communication and Inflammation Unit, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Madrid, Spain.ORCID http://orcid.org/0000-0001-7447-694X
Álvaro Fernández-AlmeidaTissue and Organ Homeostasis Program, Cell-Cell Communication and Inflammation Unit, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Madrid, Spain.ORCID http://orcid.org/0009-0006-1483-4585
Alice LeandriTissue and Organ Homeostasis Program, Cell-Cell Communication and Inflammation Unit, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Madrid, Spain.
Andrea CugurraDivision of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Eva María BlancoTissue and Organ Homeostasis Program, Cell-Cell Communication and Inflammation Unit, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Madrid, Spain.ORCID http://orcid.org/0000-0001-5940-1827
Elia Winand-OseteTissue and Organ Homeostasis Program, Cell-Cell Communication and Inflammation Unit, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Madrid, Spain.
Pablo Ramírez-Ruiz de ErenchunTissue and Organ Homeostasis Program, Cell-Cell Communication and Inflammation Unit, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Madrid, Spain.ORCID http://orcid.org/0009-0005-3575-5918
Virginia ZoritaCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Camilla BeanDepartmental Faculty of Medicine, UniCamillus-Saint Camillus International University of Health and Medical Sciences, Rome, Italy.
Valentin BassetService and Central Laboratory of Hematology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Françoise SollyService and Central Laboratory of Hematology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Amanda GarridoTranslational Gerontology Branch, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-3140-3251
Rafael de CaboTranslational Gerontology Branch, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-2830-5693
Santos MañesDepartment of Immunology and Oncology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.ORCID http://orcid.org/0000-0001-8023-957X
Manolis PasparakisInstitute of Genetics, Centre for Molecular Medicine (CMMC) and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0002-9870-0966
Matteo IannaconeDivision of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0002-9370-2671
César CobaledaInteractions with the Environment Program, Immune System Development and function Unit, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Madrid, Spain.ORCID http://orcid.org/0000-0003-3807-9204
Olaia NaveirasLaboratory of Regenerative Hematopoiesis, Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-3434-0022
Myriam GorospeLaboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-5439-3434
María MittelbrunnTissue and Organ Homeostasis Program, Cell-Cell Communication and Inflammation Unit, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Madrid, Spain. mmittelbrunn@cbm.csic.es.ORCID http://orcid.org/0000-0003-3487-8762
Funding
Consejería de Educación, Juventud y Deporte, Comunidad de Madrid (Consejería de Educación, Juventud y Deporte de la Comunidad de Madrid) PIPF-2022/SAL-GL-25208EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) ERC-2021-CoG 101044248-Let T Be
Abstract
Age-associated hematopoietic skewing results in an increase in the neutrophil-to-lymphocyte ratio, which serves as a strong predictor of all-cause mortality in older adults, although its causes are incompletely understood. Here we show that cytotoxic CD4
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.