Evidence map›Paper›PMID 42649410›Full record

ArticleNature microbiology2026

Large eukaryotic DNA viruses encode ESCRT machinery for membrane remodelling.

Sofia Medvedeva, Ulysse Guyet, Eugene V Koonin, Tom O Delmont, Mart Krupovic

Abstract read
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In one paragraph

Article in Nature microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sofia MedvedevaInstitut Pasteur, Université Paris Cité, Cell Biology and Virology of Archaea Unit, Paris, France. sofia.medvedeva@pasteur.fr.ORCID http://orcid.org/0000-0002-7841-0814
Ulysse GuyetGénomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Université Evry, Université Paris-Saclay, Evry, France.ORCID http://orcid.org/0000-0002-3603-5382
Eugene V KooninComputational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-3943-8299
Tom O DelmontGénomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Université Evry, Université Paris-Saclay, Evry, France.ORCID http://orcid.org/0000-0001-7053-7848
Mart KrupovicInstitut Pasteur, Université Paris Cité, Cell Biology and Virology of Archaea Unit, Paris, France. mart.krupovic@pasteur.fr.ORCID http://orcid.org/0000-0001-5486-0098

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-23-CE02-0022U.S. Department of Health & Human Services | NIH | U.S. National Library of Medicine (NLM) Intramural Research Program
6 · The paper itself

Abstract

The endosomal sorting complexes required for transport (ESCRT) is a membrane-remodelling machinery that mediates membrane constriction and scission. Most enveloped eukaryotic viruses exploit host ESCRT during membrane budding, but none is known to encode ESCRT components. Here, we discovered homologues of two core ESCRT components, ESCRT-III and ATPase Vps4, in mirusviruses and some viruses in the phylum Nucleocytoviricota that infect unicellular eukaryotes. Mirusviruses seem to have hijacked host ESCRT machinery early in their evolution.

Identifiers

PMID42649410

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.