Evidence map›Paper›PMID 42649342›Full record

ArticleCardiovascular and interventional radiology2026

Clinical Outcomes in Chronic Limb-Threatening Ischemia Patients Undergoing Femoropopliteal Endovascular Treatment Using IN.PACT versus Ranger: Results of the PEPPERMINT Study.

Satoru Nagatomi, Mitsuyoshi Takahara, Taira Kobayashi, Naoki Fujimura, Terutoshi Yamaoka, Daisuke Matsuda, Takanobu Okazaki, Shingo Mochizuki, Masami Shingaki, Masayuki Endo and 17 more

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Article in Cardiovascular and interventional radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Satoru NagatomiDepartment of Radiology, Sumitomo Hospital, 5-3-20 Nakanoshima, Kita-Ku, Osaka, 530-0005, Japan. s.nagatomi1007@gmail.com.ORCID http://orcid.org/0000-0003-4919-6625
Mitsuyoshi TakaharaDepartment of Laboratory Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Taira KobayashiDepartment of Cardiovascular Surgery, JA Hiroshima General Hospital, 1-3-3 Jigozen, Hatsukaichi, Hiroshima, 738-8503, Japan.
Naoki FujimuraDepartment of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
Terutoshi YamaokaDepartment of Vascular Surgery, Matsuyama Red Cross Hospital, 1 Bunkyocho, Matsuyama, Ehime, 790-8524, Japan.
Daisuke MatsudaDepartment of Vascular Surgery, Matsuyama Red Cross Hospital, 1 Bunkyocho, Matsuyama, Ehime, 790-8524, Japan.
Takanobu OkazakiDepartment of Laboratory Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Shingo MochizukiDepartment of Cardiovascular Surgery, Tsuchiya General Hospital, 3-30 Nakajimacho, Naka-Ku, Hiroshima, Hiroshima, 730-0811, Japan.
Masami ShingakiDepartment of Cardiovascular Surgery, Hakodate Municipal Hospital, 1-10-1 Minatomachi, Hakodate, Hokkaido, 041-0821, Japan.
Masayuki EndoDepartment of Radiology, Tottori University Hospital, 36-1 Nishimachi, Yonago, Tottori, 683-8504, Japan.
Kyosuke HosokawaDepartment of Vascular Surgery, Tokyo Saiseikai Central Hospital, 1-4-17 Mita, Minato-Ku, Tokyo, 108-0073, Japan.
Tadashi FuruyamaDepartment of Vascular Surgery, Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-Ku, Fukuoka, Fukuoka, 810-8563, Japan.
Tsunehiro ShintaniDepartment of Vascular Surgery, Shizuoka Red Cross Hospital, 8-2 Ohtemachi, Aoi-Ku, Shizuoka, 420-0853, Japan.
Yasuhito SekimotoDepartment of Surgery, Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-Ku, Tokyo, 152-8902, Japan.
Hidetoshi UchiyamaDepartment of Vascular Surgery, Tsuchiura Kyodo General Hospital, 4-1-1 Ootsuno, Tsuchiura, Ibaraki, 300-0028, Japan.
Ryoichi KyuragiDepartment of Surgery, Saiseikai Karatsu Hospital, 817 Motohatamachi, Karatsu, Saga, 847-0852, Japan.
Susumu WatadaDepartment of Surgery, Kawasaki Municipal Hospital, 12-1 Shinkawadori, Kawasaki-Ku, Kawasaki, Kanagawa, 210-0013, Japan.
Koichi MorisakiDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, Fukuoka, 812-8582, Japan.
Hiroki MitsuokaDepartment of Vascular Surgery, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Yohei KawaiDepartment of Vascular Surgery, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Hiroshi BannoDivision of Vascular and Endovascular Surgery, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan.
Keita HayashiDepartment of Vascular Surgery, Hiratsuka City Hospital, 1-19-1 Minamihara, Hiratsuka, Kanagawa, 254-0065, Japan.
Tsuyoshi ShibataDepartment of Cardiovascular Surgery, Sapporo Medical University, 17 Minamiichijonishi, Chuo-Ku, Sapporo, Hokkaido, 060-8556, Japan.
Shunsuke KameiDepartment of Radiology, Tokai University Hachioji Hospital, 1838 Ishikawamachi, Hachioji, Tokyo, 192-0032, Japan.
Hideaki ObaraDepartment of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
Shigeo IchihashiDepartment of Radiology, Nara Medical University, 840 Shijocho, Kashihara, Nara, 634-8521, Japan.
PEPPERMINT Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the clinical outcomes of high-dose PCB (HD-PCB) and low-dose PCB (LD-PCB) in patients with chronic limb-threatening ischemia (CLTI). MATERIALS AND

methodsThis study is a multicenter retrospective observational study conducted at 21 institutions in Japan. Patients with CLTI who underwent femoropopliteal endovascular treatment using IN.PACT Admiral DCB (HD-PCB, 3.5 μg/mm

resultsA total of 323 patients were included (IN.PACT, n = 211; Ranger, n = 112). Median follow-up was 11.6 months. No significant difference in restenosis was observed between groups (HR 1.05; 95% CI 0.74-1.50; P = 0.78). After Bonferroni correction, slow flow occurred significantly more frequently in the IN.PACT group than in the Ranger group (6.8% vs. 1.0%; OR 11.9; 99.5% CI 1.27-59.3; P = 0.002). No significant intergroup differences were observed in target lesion revascularization, major adverse limb events, wound healing, major amputation, or mortality.

conclusionsTreatment outcomes for femoropopliteal lesions in patients with CLTI were comparable between the IN.PACT Admiral and Ranger DCBs. However, slow-flow phenomenon was observed more frequently in the IN.PACT group, warranting further investigation. LEVEL OF EVIDENCE: Level 3, Cohort Study.

Indexed as

Distal embolizationDrug-coated balloonFemoropopliteal arteryPaclitaxelSlow flow

Identifiers

PMID42649342

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.