Evidence map›Paper›PMID 42649318›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

A mechanistic approach about oxidative, mutagenic, and cytotoxic effects of an organotellurane.

Felipe Emannuel Alvino de Jesus, Octávio Augusto de Carvalho Maia, Antonielly Campinho Dos Reis, Audinei de Sousa Moura, Anderson Nogueira Mendes, Glissia Lysandra Dos Santos Marciel, Jefferson da Cruz Esteves, Shamya Gabriella Corrêa Coêlho, Isabela Ribeiro de Sá Guimarães Nolêto, Maria Luísa Lima Barreto do Nascimento and 7 more

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Felipe Emannuel Alvino de JesusLaboratory of Research in Toxicological Genetics (Lapgenic), Federal University of Piauí, Teresina, Brazil.ORCID http://orcid.org/0009-0008-2227-9942
Octávio Augusto de Carvalho MaiaLaboratory of Research in Toxicological Genetics (Lapgenic), Federal University of Piauí, Teresina, Brazil.ORCID http://orcid.org/0000-0001-8932-4295
Antonielly Campinho Dos ReisLaboratory of Research in Toxicological Genetics (Lapgenic), Federal University of Piauí, Teresina, Brazil.ORCID http://orcid.org/0000-0002-0712-9910
Audinei de Sousa MouraLaboratory of Research in Toxicological Genetics (Lapgenic), Federal University of Piauí, Teresina, Brazil.ORCID http://orcid.org/0000-0003-0408-6860
Anderson Nogueira MendesDepartment of Biophysics and Physiology, Center for Health Sciences, Federal University of Piauí, Universitaria Avenue, Teresina, Piauí, 64049-550, Brazil.ORCID http://orcid.org/0000-0002-9778-3667
Glissia Lysandra Dos Santos MarcielLaboratory of Research in Toxicological Genetics (Lapgenic), Federal University of Piauí, Teresina, Brazil.ORCID http://orcid.org/0009-0006-9825-6304
Jefferson da Cruz EstevesLaboratory of Research in Toxicological Genetics (Lapgenic), Federal University of Piauí, Teresina, Brazil.ORCID http://orcid.org/0009-0003-0302-5393
Shamya Gabriella Corrêa CoêlhoLaboratory of Research in Toxicological Genetics (Lapgenic), Federal University of Piauí, Teresina, Brazil.ORCID http://orcid.org/0000-0003-0482-4376
Isabela Ribeiro de Sá Guimarães NolêtoLaboratory of Research in Toxicological Genetics (Lapgenic), Federal University of Piauí, Teresina, Brazil.ORCID http://orcid.org/0000-0001-9941-5529
Maria Luísa Lima Barreto do NascimentoLaboratory of Research in Toxicological Genetics (Lapgenic), Federal University of Piauí, Teresina, Brazil.ORCID http://orcid.org/0000-0002-2242-3392
Adriana Maria Viana NunesDepartment of Biophysics and Physiology, Center for Health Sciences, Federal University of Piauí, Universitaria Avenue, Teresina, Piauí, 64049-550, Brazil.ORCID http://orcid.org/0000-0002-6880-0683
Débora Caroline do Nascimento RodriguesLaboratory of Experimental Cancerology (LabCancer), Federal University of Piauí, Teresina, Brazil.ORCID http://orcid.org/0000-0002-1171-8013
Rodrigo Luiz Oliveira Rodrigues CunhaCenter of Natural and Human Sciences, Federal University of ABC, Santo André, Brazil.ORCID http://orcid.org/0000-0002-0203-3143
Pedro Marcos de AlmeidaFaculty of Medical Sciences, State University of Piauí, Teresina, Brazil.ORCID http://orcid.org/0000-0001-5431-6818
Dalton DittzDepartment of Biochemistry and Pharmacology, Center for Health Sciences, Federal University of Piauí, Universitaria Avenue, Teresina, Piauí, 64049-550, Brazil.ORCID http://orcid.org/0000-0002-4370-0803
Paulo Michel Pinheiro FerreiraDepartment of Biophysics and Physiology, Center for Health Sciences, Federal University of Piauí, Universitaria Avenue, Teresina, Piauí, 64049-550, Brazil. paulomichel@ufc.br.ORCID http://orcid.org/0000-0001-6862-6497
João Marcelo de Castro E SousaLaboratory of Research in Toxicological Genetics (Lapgenic), Federal University of Piauí, Teresina, Brazil. j.marcelo@ufpi.edu.br.ORCID http://orcid.org/0000-0002-5085-1482

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organotellurium (OTe) compounds have pharmacological properties, including leishmanicidal, antimalarial, and antifungal activities. Herein, we assessed cytotoxicity effects of OTe RF07 in a panel of tumor cell lines, as well as its oxidative, toxicity, and hemolytic actions. The toxicity was evaluated on Allium cepa and Artemia salina larvae. Cell viability was also assessed by resazurin in murine cells (Sarcoma 180), human cells (HL-60, leukemia; AGP01, gastric adenocarcinoma; SKMEL-28, human melanoma; MRC-5, normal fibroblasts), and dog erythrocytes. The oxidative capacity of RF07 was evaluated by wild-type and antioxidant-mutated enzyme strains of Saccharomyces cerevisiae. RF07 presented cytotoxic action on all normal and tumor cells, whose IC

Indexed as

Allium cepaChromosomal alterationsOxidative stress

Identifiers

PMID42649318

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.