Evidence map›Paper›PMID 42649302›Full record

ArticleNature2026

A binding-to-release strategy for targeted anticancer drug delivery.

Zihao Wen, Mengxin Xu, Zijun Yan, Ziren Kong, Yupeng Wang, Pei Liu, Junyi Chen, Yanzhao Liu, Xi-Yang Cui, Tianyi Cen and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Zihao Wen *Beijing National Laboratory for Molecular Sciences, Cross-disciplinary Center for f-Elements (CCFE), Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Mengxin Xu *Changping Laboratory, Beijing, China.
Zijun Yan *Beijing National Laboratory for Molecular Sciences, Cross-disciplinary Center for f-Elements (CCFE), Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Ziren Kong *Changping Laboratory, Beijing, China.ORCID http://orcid.org/0000-0001-6588-4757
Yupeng WangPyrotech (Beijing) Biotechnology, Beijing, China.
Pei LiuChangping Laboratory, Beijing, China.
Junyi ChenBeijing National Laboratory for Molecular Sciences, Cross-disciplinary Center for f-Elements (CCFE), Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-8129-1473
Yanzhao LiuKey Laboratory of Carcinogenesis and Translational Research of Ministry of Education, Key Laboratory for Research and Evaluation of Radiopharmaceuticals of National Medical Products Administration, Department of Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China.
Xi-Yang CuiChangping Laboratory, Beijing, China.
Tianyi CenChangping Laboratory, Beijing, China.
Xinwei LiChangping Laboratory, Beijing, China.
Yuedan ZhengBeijing National Laboratory for Molecular Sciences, Cross-disciplinary Center for f-Elements (CCFE), Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Zichen GuBeijing National Laboratory for Molecular Sciences, Cross-disciplinary Center for f-Elements (CCFE), Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Da XuKey Laboratory of Carcinogenesis and Translational Research of Ministry of Education, Department of Hepatopancreatobiliary Surgery, Peking University Cancer Hospital and Institute, Beijing, China.
Qiang XuDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yaping LuoDepartment of Nuclear Medicine, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Changlun WangChangping Laboratory, Beijing, China.
Zhibo LiuBeijing National Laboratory for Molecular Sciences, Cross-disciplinary Center for f-Elements (CCFE), Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China. zbliu@pku.edu.cn.ORCID http://orcid.org/0000-0002-1438-0062

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug conjugates, such as antibody-drug conjugates (ADCs) and small molecule-drug conjugates (SMDCs), are often dependent on efficient receptor-mediated endocytosis for payload release

Identifiers

PMID42649302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.