Cell-type-specific eQTLs underlie the genetic architecture of complex traits.

Minhui Chen, Xinpei Wang, Lena Krockenberger, Rika Tyebally, Jeremy J Berg, Sebastian Pott, Jonathan Flint, Joseph E Powell, Brunilda Balliu, Xuanyao Liu and 1 more

Abstract read

PubMed Publisher

In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Minhui ChenSection of Genetic Medicine, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-5684-2504

Xinpei WangSection of Genetic Medicine, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0009-0009-4997-9786

Lena KrockenbergerBioinformatics Interdepartmental Graduate Program, University of Californaia, Los Angeles, Los Angeles, CA, USA.

Rika TyeballyTranslational Genomics, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.

Jeremy J BergDepartment of Human Genetics, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-5411-6840

Sebastian PottSection of Genetic Medicine, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-4118-6150

Jonathan FlintDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-9427-4429

Joseph E PowellTranslational Genomics, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.ORCID http://orcid.org/0000-0002-5070-4124

Brunilda BalliuDepartment of Pathology and Laboratory Medicine, Department of Computational Medicine, Department of Biostatistics, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-8953-804X

Xuanyao LiuSection of Genetic Medicine, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-5955-6738

Andy DahlSection of Genetic Medicine, University of Chicago, Chicago, IL, USA. andywdahl@uchicago.edu.ORCID http://orcid.org/0000-0001-6520-4766

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic effects on complex traits primarily act by regulating gene expression; however, this process is not well understood

Identifiers

PMID42649298

DOI10.1016/j.ajhg.2024.10.009

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.