Evidence map›Paper›PMID 42649286›Full record

ArticleNature2026

Gasdermin D-mediated delivery of caspase inhibitors to suppress pyroptosis.

Katarzyna M Groborz, Melissa E Truong, Irma Stowe, Katherine E Wickliffe, Bettina Lee, Stefan Bauernfried, Robert S Jones, Emile Plise, Elizabeth S Levy, Ponien Kou and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Katarzyna M Groborz *Physiological Chemistry Department, Genentech, South San Francisco, CA, USA.
Melissa E Truong *Physiological Chemistry Department, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1526-1521
Irma StowePhysiological Chemistry Department, Genentech, South San Francisco, CA, USA.
Katherine E WickliffePhysiological Chemistry Department, Genentech, South San Francisco, CA, USA.
Bettina LeePhysiological Chemistry Department, Genentech, South San Francisco, CA, USA.
Stefan BauernfriedPhysiological Chemistry Department, Genentech, South San Francisco, CA, USA.
Robert S JonesDrug Metabolism and Pharmacokinetics Department, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-5283-8070
Emile PliseDrug Metabolism and Pharmacokinetics Department, Genentech, South San Francisco, CA, USA.
Elizabeth S LevySmall Molecule Pharmaceutics Department, Genentech, South San Francisco, CA, USA.
Ponien KouSmall Molecule Pharmaceutics Department, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0009-0008-2605-1398
Wyne P LeeTranslational Immunology Department, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3415-2710
Juan ZhangTranslational Immunology Department, Genentech, South San Francisco, CA, USA.
Hanna BudayevaProteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA.
Christopher M RoseProteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA.
Julia NguyenDepartment of Chemical Biology and Bioimaging, Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw, Poland.ORCID http://orcid.org/0009-0009-8518-2328
Malgorzata KalinkaDepartment of Chemical Biology and Bioimaging, Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw, Poland.
Marcin DragDepartment of Chemical Biology and Bioimaging, Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw, Poland.
Nobuhiko KayagakiPhysiological Chemistry Department, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8129-1740
Kim NewtonPhysiological Chemistry Department, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-4197-0340
Marcin PorebaDepartment of Chemical Biology and Bioimaging, Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw, Poland. marcin.poreba@pwr.edu.pl.ORCID http://orcid.org/0000-0002-0214-6252
Vishva M DixitPhysiological Chemistry Department, Genentech, South San Francisco, CA, USA. dixit@gene.com.ORCID http://orcid.org/0000-0001-6983-0326

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Caspase-1, -4, -5 and -11 activate gasdermin D (GSDMD) pores, causing pyroptotic cell death and the release of the interleukins IL-1β and IL-18 (ref.

Indexed as

Caspase InhibitorsIntracellular Signaling Peptides and ProteinsPhosphate-Binding ProteinsPyroptosisAnimalsApoptosis Regulatory ProteinsCaspase 1CaspasesCell Membrane PermeabilityDisease Models, AnimalFemaleGasderminsHumansInterleukin-18Interleukin-1betaMaleApoptosis Regulatory ProteinsCaspase 1Caspase InhibitorsCaspasesGasderminsGSDMD protein, humanGsdmd protein, mouseInterleukin-18Interleukin-1betaIntracellular Signaling Peptides and ProteinsPhosphate-Binding Proteins

Identifiers

PMID42649286
PMCPMC13645671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.