Evidence map›Paper›PMID 42649273›Full record

ArticleEMBO reports2026

Maternal microbiome promotes offspring ovarian reserve via bile acid metabolism.

Han Wang, Yukang Li, Yilin Niu, Xin Chen, Jing Liu, Weiting Feng, Jingru Cao, Haixia Liu, Chang Liu, Xiaoying Liang and 6 more

Abstract read
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Article in EMBO reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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4 · The record

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5 · Who and what money

Authors and funding

16 authors.

Han Wang *College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China.
Yukang Li *College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China.
Yilin Niu *College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China.
Xin Chen *College of Life Sciences, Qingdao Agricultural University, Qingdao, 266109, China.
Jing LiuCentral Laboratory of Qingdao Agricultural University, Qingdao Agricultural University, Qingdao, 266109, China.
Weiting FengCollege of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China.
Jingru CaoCollege of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China.
Haixia LiuCollege of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China.
Chang LiuCollege of Life Sciences, Qingdao Agricultural University, Qingdao, 266109, China.
Xiaoying LiangCollege of Life Sciences, Qingdao Agricultural University, Qingdao, 266109, China.
Ziqing GeCollege of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China.ORCID http://orcid.org/0009-0008-5156-8655
Junjie WangCollege of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China.ORCID http://orcid.org/0000-0002-7145-5702
Xinlei FengShandong Animal Products Quality and Safety Center, Jinan, 250100, China.
Shunfeng ChengCollege of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China.
Wei ShenCollege of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China. wshen@qau.edu.cn.ORCID http://orcid.org/0000-0001-6112-2501
Wei GeCollege of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China. gewei0901@qau.edu.cn.ORCID http://orcid.org/0000-0002-4610-7933

Funding

MOST | National Natural Science Foundation of China (NSFC) 32100683MOST | National Natural Science Foundation of China (NSFC) 32570626| Natural Science Foundation of Shandong Province ( ) ZR2021QC003Qingdao's Science and Technology Projects for People's Livehood 24-1-8-xdny-5-nshStart-up Fund for High-level Talents of Qingdao Agricultural University 6651121003Taishan Scholar Foundation of Shandong Province of China ts20190946Taishan Scholar Foundation of Shandong Province of China tsqn202211194
6 · The paper itself

Abstract

The maternal microbiome plays a crucial role in host ovarian function and fertility, yet its influence on in-utero ovarian development in offspring remains poorly understood. Here, we demonstrate that maternal antibiotic-induced microbiome disruption in mice leads to diminished ovarian reserve (DOR) in the offspring, while fecal microbiota transplantation (FMT) alleviates this effect. Metabolomic analysis reveals that maternal microbiome disruption alters metabolomic profiles in the maternal serum, with pathway enrichment analysis indicating reduced bile acid secretion in the maternal serum of ABX dams. Importantly, supplementation of key bile acid metabolites and transplantation of Lactobacillus gasseri (L. gasseri), a known promoter of bile acid metabolism, to antibiotic-treated dams abrogated maternal microbiome disruption-induced DOR. Additionally, through in vitro fertilization assay, we found that maternal microbiome disruption impaired oocyte quality in offspring, while FMT and supplementation with bile acid metabolites alleviated this effect. Together, our findings highlight the critical role of the maternal microbiome in offspring fertility, potentially through microbially mediated bile acid metabolism in the maternal serum.

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PMID42649273

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