Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Fabiana San MartinInstitut Pasteur de Montevideo, Laboratory of Molecular & Structural Microbiology, Montevideo, Uruguay.
Megan R Brady *Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
Lenka Fule *Institut Pasteur, Université Paris Cité, Biology of Spirochetes Unit, Paris, France.
Lucienne NouchikianInstitut Pasteur, Université Paris Cité, CNRS UAR 2024, Mass Spectrometry for Biology Unit, Paris, France.
Azalia RodriguezInstitut Pasteur de Montevideo & Instituto de Investigaciones Biologicas Clemente Estable, Analytical Biochemistry and Proteomics Unit, Montevideo, Uruguay.
Magalie DuchateauInstitut Pasteur, Université Paris Cité, CNRS UAR 2024, Mass Spectrometry for Biology Unit, Paris, France.ORCID 0000-0001-5475-3065
Sonia MondinoInstitut Pasteur de Montevideo, Laboratory of Molecular & Structural Microbiology, Montevideo, Uruguay.ORCID 0009-0002-8637-2210
Nicole LarrieuxInstitut Pasteur de Montevideo, Laboratory of Molecular & Structural Microbiology, Montevideo, Uruguay.ORCID 0000-0002-8027-9544
Elsio A WunderDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.ORCID 0000-0002-5239-8511
Albert I KoDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.ORCID 0000-0001-9023-2339
Martial ReyInstitut Pasteur, Université Paris Cité, CNRS UAR 2024, Mass Spectrometry for Biology Unit, Paris, France.ORCID 0000-0002-7378-1106
Julia Chamot-RookeInstitut Pasteur, Université Paris Cité, CNRS UAR 2024, Mass Spectrometry for Biology Unit, Paris, France.ORCID 0000-0002-9427-543X
Rosario DuranInstitut Pasteur de Montevideo & Instituto de Investigaciones Biologicas Clemente Estable, Analytical Biochemistry and Proteomics Unit, Montevideo, Uruguay.ORCID 0000-0002-8575-9651
Felipe TrajtenbergInstitut Pasteur de Montevideo, Laboratory of Molecular & Structural Microbiology, Montevideo, Uruguay.ORCID 0000-0003-0427-5549
Mathieu PicardeauInstitut Pasteur, Université Paris Cité, Biology of Spirochetes Unit, Paris, France.ORCID 0000-0002-5338-5579
Charles V SindelarDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA. charles.sindelar@yale.edu.ORCID 0000-0002-6646-7776
Alejandro BuschiazzoInstitut Pasteur de Montevideo, Laboratory of Molecular & Structural Microbiology, Montevideo, Uruguay. alebus@pasteur.edu.uy.ORCID 0000-0002-2509-6526
Funding
Virulence and Adaptation to the Host Environment of Pathogenic LeptospiraP01AI168148 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAVID A HAAKE · 2023 to 2026
$11.8M
PREDOCTORAL PROGRAM IN BIOPHYSICST32GM008283 · NIGMS · YALE UNIVERSITY · PI XIONG, YONG · 1988 to 2022
$10.5M
Structural basis of motility by dimeric kinesin motor proteinsR01GM110530 · NIGMS · YALE UNIVERSITY · PI SINDELAR, CHARLES VAUGHN · 2014 to 2023
$3.0M
Natural History of Urban LeptospirosisR01AI052473 · NIAID · YALE UNIVERSITY · PI KO, ALBERT ICKSANG · 2003 to 2013
$2.8M
Development of a Universal Vaccine Against LeptospirosisR01AI182354 · NIAID · UNIVERSITY OF CONNECTICUT STORRS · PI Elsio Augusto Wunder · 2024 to 2026
$2.3M
Elucidating a novel flagellar architecture from the pathogenic spirochete Leptospira and its role in motilityR56AI145326 · NIAID · YALE UNIVERSITY · PI KO, ALBERT ICKSANG, SINDELAR, CHARLES VAUGHN · 2020 to 2020
$566k
Evolutionary multispecies transcriptomics to reveal genes conferring pathogenicity within Leptospira sppR21AI163663 · NIAID · YALE UNIVERSITY · PI TOWNSEND, JEFFREY PETER, WUNDER, ELSIO AUGUSTO · 2021 to 2022
$461k
Agence Nationale de la Recherche (French National Research Agency) 18-CE15-0027-01Agencia Nacional de Investigación e Innovación (National Agency for Research and Innovation) FCE_1_2025_1_186367Institut Pasteur PIU LEPNETNIAID NIH HHS P01 AI168148NIAID NIH HHS R01 AI052473NIAID NIH HHS R01 AI182354NIAID NIH HHS R21 AI163663NIAID NIH HHS R56 AI145326NIGMS NIH HHS R01 GM110530NIGMS NIH HHS T32 GM008283U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) P01 AI168148U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01 AI052473U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01 AI182354U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21 AI163663U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R56 AI145326U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01 GM110530
6 · The paper itself
Abstract
Spirochaete pathogens are among the most invasive bacteria known, causing syphilis, Lyme disease, and leptospirosis. Their tissue penetration depends on periplasmic flagellar filaments that, unlike other bacterial flagella, are encased in a spirochaete-specific multi-protein sheath and deform the cell body into motile waves. How these filaments achieve the mechanical properties needed for invasive motility has remained unclear. Here we determine complete atomic structures of the Leptospira endoflagellar filament, revealing an elaborate sheath of 9 to 12 distinct asymmetrically arranged proteins. We show that the flagellin variant forming the filament core determines sheath composition, producing curvatures ranging from ~3.5 µm
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Core-sheath coupling controls flagellar curvature and motility in Leptospira. · full record | OpenQuestion