Evidence map›Paper›PMID 42649196›Full record

ArticleNature communications2026

Neural dynamics for working memory and evidence integration during olfactory navigation in Drosophila.

Nicholas D Kathman, Aaron J Lanz, Jacob D Freed, Katherine I Nagel

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Odor tracking in flyingProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Ballistic food approaches inbioRxiv : the preprint server for biology · 2026
    Article
  7. Odor tracking in flyingbioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. A vector-based strategy for olfactory navigation inbioRxiv : the preprint server for biology · 2025
    Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Nicholas D KathmanDepartment of Neuroscience, NYU School of Medicine, New York, NY, USA.ORCID 0000-0002-8719-6397
Aaron J LanzDepartment of Neuroscience, NYU School of Medicine, New York, NY, USA.ORCID 0000-0002-1217-9154
Jacob D FreedDepartment of Neuroscience, NYU School of Medicine, New York, NY, USA.ORCID 0009-0009-4324-6418
Katherine I NagelDepartment of Neuroscience, NYU School of Medicine, New York, NY, USA. katherine.nagel@nyulangone.org.ORCID 0000-0002-6701-3901

Funding

Neural Circuits Underlying Multisensory Control of Orientation in DrosophilaR01DC017979 · NIDCD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Katherine Nagel · 2019 to 2026
$3.8M
The Neural Circuit Basis of Olfactory Navigation in Adult DrosophilaRF1NS127129 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NAGEL, KATHERINE · 2022 to 2022
$1.7M
The Neural Circuit Basis of Olfactory Navigation in Adult DrosophilaR01NS127129 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Katherine Nagel · 2025 to 2026
$1.0M
National Science Foundation (NSF) NSF 2014217NIDCD NIH HHS R01 DC017979NINDS NIH HHS R01 NS127129NINDS NIH HHS RF1 NS127129U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS127129U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) DC017979
6 · The paper itself

Abstract

Working memory and evidence integration are fundamental components of cognition. Theoretical and behavioral studies argue that both processes are required for plume navigation, a behavior in which animals use stochastic sensory cues to navigate towards an odor source. Here we identify a small population of local neurons in the navigation center of Drosophila that exhibits both theorized processes. During virtual plume navigation, a bump of activity in this population ramps up with successive odor encounters, and can persist for variable intervals after odor loss. While the bump persists, the fly maintains the goal heading it adopted during odor. Silencing these neurons impairs this persistence. Simulations show that the time constant of persistence observed in these neurons optimizes navigation in a turbulent boundary layer plume. Our work localizes working memory and evidence integration to a specific group of neurons, which will facilitate the mechanistic dissection of these building blocks of cognition.

Indexed as

Drosophila melanogasterMemory, Short-TermNeuronsSmellSpatial NavigationAnimalsDrosophilaFemaleOdorants

Identifiers

PMID42649196
PMCPMC13518903

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.