Evidence map›Paper›PMID 42649169›Full record

ArticleNature communications2026

Cross-species comparative spatial transcriptomics of hair follicle-T cell interactions identifies conserved drivers of cutaneous lupus erythematosus skin disease and associated hair loss.

Ümmügülsüm Yıldız-Altay, Rutha Adhanom, Warda Abdi, Andrew Romasco, Lauren You, Nuha Salam, Robert Li, Haya Raef, Yuying Zhang, Elise Santacruz and 19 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Ümmügülsüm Yıldız-AltayDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-8774-9257
Rutha AdhanomDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, USA.
Warda AbdiDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, USA.
Andrew RomascoDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, USA.
Lauren YouDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, USA.
Nuha SalamDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, USA.
Robert LiDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, USA.
Haya RaefDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, USA.
Yuying ZhangDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, USA.
Elise SantacruzDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, USA.ORCID 0009-0002-9943-162X
Katelin MurphyDepartment of Comparative Pathobiology, Tufts Cummings School of Veterinary Medicine, North Grafton, MA, USA.
Saeed ShakibaDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, USA.
Mridushi DagaDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, USA.
Qi TangDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-8913-0519
Matthew OliveraDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, USA.ORCID 0009-0003-2994-8225
Thomas CicutoDepartment of Microbiology, Sanderson Center for Optical Experimentation, UMass Chan Medical School, Worcester, MA, USA.
Floriane BretheauBliq Photonics, Quebec City, QC, Canada.
Ann Marshak-RothsteinDepartment of Medicine, Division of Rheumatology, UMass Chan Medical School, Worcester, MA, USA.ORCID 0000-0003-2136-8130
Michael D RosenblumDepartment of Dermatology, UCSF, San Francisco, CA, USA.ORCID 0000-0002-0462-5732
Christina E BaerRNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-8909-2583
Motahareh ArjomandnejadGene Therapy Center, UMass Chan Medical School, Worcester, MA, USA.
Allison KeelerGene Therapy Center, UMass Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-5202-4616
Helen BuiDepartment of Dermatology, Howard University College of Medicine, Washington, DC, USA.ORCID 0000-0001-9058-8829
Amanda MartinotDepartment of Comparative Pathobiology, Tufts Cummings School of Veterinary Medicine, North Grafton, MA, USA.ORCID 0000-0001-6237-6191
Babak ShokraniDepartment of Pathology, Howard University College of Medicine, Washington, DC, USA.
Ramon AlmelaDepartment of Clinical Sciences, Tufts Cummings School of Veterinary Medicine, North Grafton, MA, USA.
Angel S ByrdDepartment of Dermatology, Howard University College of Medicine, Washington, DC, USA.
Cheri FreyDepartment of Dermatology, Howard University College of Medicine, Washington, DC, USA.
Jillian M RichmondDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, USA. jillian.richmond@tufts.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous lupus erythematosus (CLE) encompasses several autoimmune entities characterized by a T cell-rich infiltrate and alopecia. Here, we perform spatial transcriptomics across three mammalian species to characterize potential T cell-hair follicle communication pathways in the microanatomical niche. In mice, adoptive transfer of either autoreactive CD4 + /OT2 or CD8 + /OT1 T results in skin disease with 35% gene expression overlap. CD8 T cells specifically contribute to extracellular matrix reorganization. Digital spatial profiling of skin identifies CXCR3 ligands and IFN response genes in hair follicles, also conserved in pet dog and human Discoid lupus erythematosus (DLE) biopsies. Knock-out of CXCR3 on OT2 T cells alleviates skin disease in CLE mice. Moreover, B cell depletion in OT1 CLE recipient mice reduces skin disease scores as relevant to human B cell depletion therapies for lupus. Last, we identify CFD and S100A8/9 as conserved targets that could be further explored through future veterinary and human trials.

Indexed as

AlopeciaHair FollicleLupus Erythematosus, CutaneousT-LymphocytesAnimalsB-LymphocytesCD8-Positive T-LymphocytesCell CommunicationDogsFemaleHumansLupus Erythematosus, DiscoidMiceSkinSpatial TranscriptomicsSpecies Specificity

Identifiers

PMID42649169
PMCPMC13518917

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.