Evidence map›Paper›PMID 42648889›Full record

ReviewJournal of oral rehabilitation2026

Understanding Diagnostic Failure in Temporomandibular Disorders: A Narrative Synthesis of Evidence and Five-Domain Framework for Iatrogenic Mismanagement.

Bernardo Correia Lima, Rayan Eboli Fortunato, Leonardo Brígido Metello Neves, Ricardo Grillo, Mariana Aparedida Brozoski, Fernando Melhem-Elias, Janey Prodoehl, Louis G Mercuri

Abstract readReview
In one paragraph

Review in Journal of oral rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bernardo Correia LimaDepartment of Oral and Maxillofacial Surgery, Prosthesis and Traumatology, University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-4784-3120
Rayan Eboli FortunatoPost Graduate Program, Department of Orofacial Pain, Arthur Sá Earp Neto University, Petrópolis, Brazil.
Leonardo Brígido Metello NevesDepartment of Oral and Maxillofacial Surgery, Prosthesis and Traumatology, University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-3857-0522
Ricardo GrilloDepartment of Oral and Maxillofacial Surgery, Prosthesis and Traumatology, University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-8096-738X
Mariana Aparedida BrozoskiDepartment of Oral and Maxillofacial Surgery, Prosthesis and Traumatology, University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-4669-4418
Fernando Melhem-EliasDepartment of Oral and Maxillofacial Surgery, Prosthesis and Traumatology, University of São Paulo, São Paulo, Brazil.
Janey ProdoehlPhysical Therapy Program and College of Dental Medicine-Illinois, Midwestern University, Downers Grove, Illinois, USA.ORCID https://orcid.org/0000-0002-1814-9343
Louis G MercuriDepartment of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiagnostic errors in temporomandibular disorders (TMDs) contribute to unnecessary procedures and avoidable patient mismanagement despite advances in pain science, diagnostic classification systems, and evidence-based care.

objectiveTo conduct a narrative review and present a dynamic, five-domain framework explaining how diagnostic uncertainty interacts with educational, cognitive, systemic, and ethical factors to produce iatrogenic overtreatment.

methodsSearches of PubMed, Scopus, Web of Science, and Google Scholar (inception to April 2026) identified literature on TMD diagnosis, clinical reasoning, dental education, health system organization, and bioethics. Concepts were synthesized into interacting thematic domains.

resultsFive dynamic, interacting domains were identified: (1) Educational Deficits, (2) Structural Reductionism, (3) Occlusal Overinterpretation, (4) System Fragmentation, and (5) Ethical Dissonance. The model demonstrates how educational gaps foster reductionist diagnostic paradigms, which are amplified by health-system silos and defensive clinical practices, increasing the likelihood of non-indicated, irreversible interventions.

conclusionsThe Five-Domain Framework offers a systemic model for understanding diagnostic breakdown in TMD management, providing a structured foundation for educational reform, integrated care pathways, and future empirical research.

Indexed as

Diagnostic ErrorsIatrogenic DiseaseTemporomandibular Joint DisordersHumansOvertreatmentclinical reasoningdental educationdiagnostic erroriatrogenic harmorofacial painovertreatmentpatient safetytemporomandibular disorders

Identifiers

PMID42648889
PMCPMC13653307

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.