ArticleNeuroImage2026
Aging, brain network connectivity, and cognition: evidence from resting-state dynamic arterial spin labeling.
Article in NeuroImage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionBackground-suppressed dynamic arterial spin labeling (bDASL) has emerged as a robust method for measuring functional connectivity with substantially reduced systemic noise. We leveraged bDASL to characterize age-related changes in resting-state functional connectivity (rsFC) and to examine how these changes correlate with cognitive performance across the lifespan.
methodsA total of 139 healthy adults underwent rsFC measurements using bDASL, among whom 115 also completed cognitive assessments. Group independent component analysis (ICA) was employed to identify four high-order resting-state networks: the default mode (DMN), dorsal attention (DAN), salience (SN), and frontoparietal control (FPN) networks. Seed-based analyses were then used to quantify intra- and inter-network rsFC. Multiple linear regressions were conducted to study these relationships.
resultsOur findings demonstrate that aging was associated with widespread reductions in both intra-network connectivity within all four networks, and inter-network connectivity among the DMN-SN, DAN-SN, and FPN-SN. These connectivity differences were associated with diminished global signal fluctuations, suggesting that alterations in brain-wide dynamics accompany age-related changes in functional network organization. Crucially, the relationship between network connectivity and executive function differed by age, with preserved DAN-centered connectivity showing a strong association with executive function in older adults.
conclusionAlthough aging was associated with widespread reductions in functional connectivity, older adults who preserved greater intra-network DAN connectivity and stronger inter-network connectivity between the DAN and the DMN, SN, and FPN exhibited better executive function. These findings suggest that maintaining DAN-centered communication may contribute to cognitive resilience during healthy aging. Collectively, this work provides insight into patterns of functional reorganization associated with the aging brain and identifies DAN-centered integration as a potential marker of cognitive resilience.
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