Evidence map›Paper›PMID 42648291›Full record

ArticleNeuron2026

Ingestion-activated CGRP neurons control learning but not satiety.

Brooke C Jarvie, Anagh Ravi, Rhea Nanavati, Ho Namkung, Longhui Qiu, Truong Ly, Jun Y Oh, Olivia K Barnhill, Zachary A Knight

Abstract read
PubMed Publisher
In one paragraph

Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Brooke C JarvieDepartment of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.
Anagh RaviNeuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.
Rhea NanavatiHoward Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
Ho NamkungDepartment of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Center for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA.
Longhui QiuDepartment of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.
Truong LyNeuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.
Jun Y OhDepartment of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.
Olivia K BarnhillNeuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.
Zachary A KnightDepartment of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Center for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: zachary.knight@ucsf.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcitonin gene-related peptide (CGRP) neurons in the parabrachial nucleus are critical for sickness and malaise but have also been proposed to control non-aversive (rewarding) satiation. How one cell type coordinates these opposing processes has not been explained. Here, we reinvestigate the function of these cells using single-cell imaging as well as optical and chemogenetic manipulations in mice. Contrary to current models, we show that CGRP neurons do not track cumulative food consumption, and their activity is not necessary for meal termination. Instead, we identify two distinct populations of CGRP cells, one of which responds rapidly to appetitive signals during ingestion and the other of which responds slowly to aversive visceral cues. Surprisingly, the ingestion-activated CGRP neurons are important for learning about post-ingestive effects but have little effect on food consumption. This reveals two populations of CGRP neurons that are sequentially engaged during, and responsible for, distinct stages of post-ingestive learning.

Indexed as

calcium imagingconditioned taste aversionhungermicroendoscopynauseaneural circuitoptogeneticsparabrachialsatietysicknesstaste

Identifiers

PMID42648291

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.