ArticleStem cell research2026
Generation of two induced pluripotent stem cell lines from Marfan syndrome patients carrying FBN1 mutations.
Byron W H Mui, Mey-Sam Chorsi, Christopher D Yan, Jade T Chao, Joseph C Wu
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In one paragraphArticle in Stem cell research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
5 authors.
Byron W H MuiStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Mey-Sam ChorsiStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Christopher D YanGreenstone Biosciences, Palo Alto, CA 94305, USA.
Jade T ChaoGreenstone Biosciences, Palo Alto, CA 94305, USA.
Joseph C WuStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: joewu@stanford.edu.
Funding
Single Cell Sequencing of Human iPSC-CM Subtype Identity and FunctionR01HL145676 · NHLBI · STANFORD UNIVERSITY · PI MARK MERCOLA, Joseph C. Wu · 2019 to 2026
$5.1MMulti-Disciplinary Training Program in Cardiovascular Imaging at StanfordT32EB009035 · NIBIB · STANFORD UNIVERSITY · PI Koen Nieman, John M. Pauly · 2008 to 2026
$4.3MAdvancing Personalized Cardiac Organoids - Converging In Vitro, In Chemico, and In Silico ModelsUM1TR006031 · NCATS · STANFORD UNIVERSITY · PI Afshin Beheshti, Sarah C Heilshorn · 2026 to 2026
$3.1MComputational Medicine in the Heart, Integrated Training ProgramT32HL166155 · NHLBI · STANFORD UNIVERSITY · PI Alison L Marsden, Sanjiv M Narayan · 2023 to 2026
$2.0MUnraveling Proteasome Inhibitor-Induced Cardiovascular Toxicity through Integrative MultiomicsR01HL176822 · NHLBI · STANFORD UNIVERSITY · PI MARK MERCOLA, Joseph C. Wu · 2025 to 2026
$1.4MNCATS NIH HHS UM1 TR006031NHLBI NIH HHS R01 HL145676NHLBI NIH HHS R01 HL176822NHLBI NIH HHS T32 HL166155NIBIB NIH HHS T32 EB009035
6 · The paper itselfAbstract
Marfan syndrome is a connective tissue disorder affecting the cardiovascular, skeletal, and ocular systems. Here, we generated and characterized induced pluripotent stem cell (iPSC) lines derived from two Marfan syndrome patients with mutations in the FBN1 gene (c.3333C > A and c.8854_8562delinsTATCAC). Both lines exhibited typical iPSC morphology, normal karyotype, undifferentiated states, and trilineage differentiation capacity. These iPSCs serve to enable investigation into the mechanisms underlying Marfan syndrome for therapeutic discovery.
Indexed as
Fibrillin-1Induced Pluripotent Stem CellsMarfan SyndromeMutationAdipokinesCell DifferentiationCell LineFemaleHumansMaleAdipokinesFBN1 protein, humanFibrillin-1
Identifiers
PMID42648118
PMCPMC13634669
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