Evidence map›Paper›PMID 42648009›Full record

Observational studyJournal of the American Medical Directors Association2026

Oral Anticoagulant Use Among Residents in VA Long-Term Care With Atrial Fibrillation After the 2014 ACC/AHA Guideline.

Veena Manja, Yongmei Li, Michael A Steinman, Sei Lee, Laura A Graham, Bocheng Jing, Kathy Fung, Xiaojuan Liu, Steven M Asch, Michelle C Odden

Abstract readObservational Study
In one paragraph

Observational study in Journal of the American Medical Directors Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Veena ManjaDepartment of Medicine, VA Northern California Healthcare System, Mather, CA, USA; Department of Medicine, UC Davis School of Medicine, Sacramento, CA, USA.
Yongmei LiDepartment of Epidemiology and Population Health, Stanford School of Medicine, Stanford, CA, USA.
Michael A SteinmanDivision of Geriatrics, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Sei LeeDivision of Geriatrics, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Laura A GrahamHealth Economic Resource Center, VA Palo Alto Health Care System, Palo Alto, CA, USA.
Bocheng JingDepartment of Epidemiology and Population Health, Stanford School of Medicine, Stanford, CA, USA.
Kathy FungDivision of Geriatrics, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA.
Xiaojuan LiuDivision of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Steven M AschVA HSR&D Center for Innovation to Implementation, VA Palo Alto Health Care System, Palo Alto, CA, USA; Division of Primary Care and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Michelle C OddenDepartment of Epidemiology and Population Health, Stanford School of Medicine, Stanford, CA, USA. Electronic address: modden@stanford.edu.

Funding

VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Louise C. Walter · 2013 to 2026
$19.9M
Deprescribing Cardiovascular Medications among Persons with and without Alzheimer's Disease and Related Dementias in Long-Term CareR01AG062568 · NIA · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI Christine Kee Liu, Michelle Christina Odden · 2024 to 2026
$2.3M
Mentoring Patient-Oriented Research to Individualize Care for Hospitalized Older Adults with and without Alzheimer's Disease and Related DementiasK24AG066998 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Sei Lee · 2021 to 2026
$1.1M
NIA NIH HHS K24 AG066998NIA NIH HHS P30 AG044281NIA NIH HHS R01 AG062568
6 · The paper itself

Abstract

objectivesIn 2014, the American College of Cardiology/American Heart Association moved away from recommending aspirin in atrial fibrillation (AF) and recommended that patients be treated with oral anticoagulants (OACs) to mitigate the risk of stroke. We aimed to evaluate the prevalence and predictors of OACs and/or aspirin use among veterans with AF in Veterans Affairs nursing homes in the era after the guideline publication.

designObservational study of veterans admitted from October 1, 2014 to September 30, 2019. SETTING AND

participantsFour thousand nine hundred ninety-four nursing home residents with AF and a CHA

methodsMultinomial logistic regression was used to compare demographics, comorbidities, functional status, and concurrent antiplatelet medication use in residents who received OAC ± aspirin and aspirin alone, compared with neither.

resultsIn the era after the 2014 American College of Cardiology/American Heart Association guideline was released, age-standardized prevalence rates for any OAC (warfarin and direct oral anticoagulant) increased from 31.2% in fiscal year (FY) 2013 to 2014 to 46.6% in FY 2019. In addition, there was a decrease in patients receiving no OAC (21.1%-16.2%) and aspirin (47.7%-39.3%). However, some eligible residents remained untreated. Averaged over FY 2015 to 2019, each decade of ascending age was associated with a lower likelihood of receiving OAC [relative risk ratio (RRR), 0.79; 95% CI, 0.71-0.87], relative to neither anticoagulant nor aspirin use. Black veterans were less likely to receive OAC (RRR, 0.73; 95% CI, 0.58-0.91); Hispanic veterans were less likely to receive OAC (RRR, 0.63; 95% CI, 0.44-0.91) and aspirin (RRR, 0.47; 95% CI, 0.31-0.72). Mild to moderate cognitive impairment, greater disability, and other antiplatelet use were also associated with less OAC use. CONCLUSIONS AND IMPLICATIONS: Fewer Veterans Affairs nursing home residents received OACs than recommended by guidelines, with significant differences by age and race/ethnicity. Future research efforts should aim to understand the reasons for low OAC use and to augment the evidence base for anticoagulant use to include frail older adults.

Indexed as

AnticoagulantsAtrial FibrillationNursing Home ResidentsPractice Guidelines as TopicAdministration, OralAgedAged, 80 and overAmerican Heart AssociationAspirinFemaleGuideline AdherenceHumansLong-Term CareMaleNursing HomesStrokeAnticoagulantsAspirinaspirinAtrial fibrillationdeprescribingnursing homeoral anticoagulationstroke prophylaxis

Identifiers

PMID42648009
PMCPMC13617581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.