Evidence map›Paper›PMID 42647928›Full record

ArticleClinical practice and cases in emergency medicine2026

Keeping An Eye Out for Stroke-Herpes Zoster Ophthalmicus Leading to Acute Ischemic Stroke.

Summer Burke, Mary Armbruster, Jacqueline Le

Abstract readCase Reports
In one paragraph

Article in Clinical practice and cases in emergency medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Summer BurkeDesert Regional Medical Center, Department of Emergency Medicine, Palm Springs, California.
Mary ArmbrusterDesert Regional Medical Center, Department of Emergency Medicine, Palm Springs, California.
Jacqueline LeDesert Regional Medical Center, Department of Emergency Medicine, Palm Springs, California.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHerpes zoster ophthalmicus, a reactivation of varicella-zoster virus involving the ophthalmic branch of the trigeminal nerve, is a known but under-recognized risk factor for acute cerebrovascular and cardiovascular events. CASE REPORT: We report the case of an 84-year-old female with herpes zoster ophthalmicus who suffered a fatal ischemic stroke and bilateral submassive pulmonary emboli within days of diagnosis. Despite early identification and appropriate antiviral treatment, the patient experienced rapid neurological decline and ultimately succumbed to complications.

conclusionThis case underscores the critical association between herpes zoster ophthalmicus and increased risk of stroke and myocardial infarction, as supported by growing epidemiologic evidence. Physicians should be aware of these severe complications, consider close monitoring and cardiovascular risk stratification in patients with herpes zoster ophthalmicus, and they should provide patients with clear return precautions for symptoms suggestive of stroke or embolic disease. Further research is needed to determine preventative strategies beyond antiviral therapy for high-risk patients.

Identifiers

PMID42647928
PMCPMC13518000

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.