ArticleClinical practice and cases in emergency medicine2026
Emergency Department Presentation of Duloxetine-induced Acute Extrapyramidal Symptoms: A Case Report.
Article in Clinical practice and cases in emergency medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionDuloxetine, a serotonin-norepinephrine reuptake inhibitor, has been associated with extrapyramidal symptoms and tardive syndromes; however, such adverse reactions are rare and remain sparsely documented, particularly in the setting of non-psychiatric use. CASE REPORT: A young, healthy, active-duty military service member developed acute extrapyramidal symptoms-restlessness, dystonic movements, and acute dystonia-shortly after initiating duloxetine for postsurgical neuropathic pain.
conclusionThis case highlights the need for vigilance regarding movement disorders in patients prescribed duloxetine, even in the absence of psychiatric comorbidity or antipsychotic exposure.
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