ReviewRhode Island medical journal (2013)2026
Impact of Maternal Smoking During Pregnancy on Fetal and Neonatal Neurobehavioral Development: A Narrative Review.
Review in Rhode Island medical journal (2013), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundMaternal smoking during pregnancy (MSDP) remains a common source of prenatal drug exposure worldwide. MSDP has been shown to increase fetal health risks and interfere with fetal development. Although newborns prenatally exposed to other substances (e.g., opiates, benzodiazepines) have been shown to have increased stress and withdrawal symptoms, few studies have explored the effect of MSDP on the fetal and neonatal periods.
methodsWe performed a comprehensive search for empirical research articles investigating the effects of MSDP on fetal and neonatal neurobehavior and signs of abstinence in PubMed and PsycINFO databases. Our search yielded 11 fetal and 14 neonatal empirical articles published between 1980 and 2025.
resultsIn the fetal period, MSDP-exposed fetuses showed decreased fetal heart rate variability, and fetal movement and reactivity vs unexposed fetuses. In the early neonatal period (birth to five days), MSDP-exposed newborns showed increased excitability, irritability, need for handling, arousal, and alertness. In the late neonatal period (10 to 35 days), studies found MSDP to have an effect on neonatal self-regulation, attention, quality of movement, abnormalities in reflexes, lethargy, need for handling, and stress signs.
conclusionsOur review of the literature revealed that MSDP has been associated with alterations in behavior suggestive of potential abstinence symptoms, especially found for excitability, irritability, hypertonicity, attention, reflex abnormalities, and stress/abstinence signs. Additional rigorous research needs to delineate the impact of MSDP on fetal and neonatal signs of abstinence to improve infant health.
Indexed as
Identifiers
42647831PMC13616101What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.