Evidence map›Paper›PMID 42647638›Full record

ArticleScience advances2026

Muscular dystrophy-associated lamin variants disrupt cellular organization through a nucleolar-ribosomal axis.

Xiangyi Ding, Sweta Kumari, Ellen F Gregory, Daniel A Starr, G W Gant Luxton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Xiangyi DingDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA, USA.ORCID 0009-0009-4831-1274
Sweta KumariDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA, USA.
Ellen F GregoryDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-2228-8258
Daniel A StarrDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA, USA.ORCID 0000-0001-7339-6606
G W Gant LuxtonDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-6180-8906

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Mechanisms of Nuclear MigrationR35GM134859 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DANIEL A STARR · 2020 to 2026
$2.8M
NIGMS NIH HHS R35 GM134859NIH HHS P40 OD010440
6 · The paper itself

Abstract

Emery-Dreifuss muscular dystrophy (EDMD) arises from mutations in nuclear lamins or emerin. Current pathological models emphasize defective nuclear mechanics and transcriptional regulation, yet these mechanisms cannot explain how lamina defects propagate across the cell to produce the complex pathology of laminopathies. Here, we reveal an emerging pathway linking nuclear lamina dysfunction to cytoplasmic reorganization. Using

Indexed as

Cell NucleolusLaminsMuscular Dystrophy, Emery-DreifussRibosomesAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCytoplasmEndoplasmic ReticulumHumansMutationNuclear LaminaNuclear ProteinsCaenorhabditis elegans ProteinsLaminsNuclear Proteins

Identifiers

PMID42647638
PMCPMC13510739

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.