Evidence map›Paper›PMID 42647628›Full record

ArticleScience advances2026

An axon-intrinsic loop restricts nerve regeneration through axonal protein synthesis.

Courtney N Buchanan, Jinyoung Lee, Samaneh Matoo, Jordan A Headen, Marie-Claire Honoree, Molly Conway, Lillian F Thompson, Terika P Smith, Ansley McKay, Cailyn Tosadori and 8 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Courtney N BuchananDepartment of Biological Sciences, University of South Carolina; Columbia, SC 29204 USA.ORCID 0000-0003-4197-1244
Jinyoung LeeDepartment of Biological Sciences, University of South Carolina; Columbia, SC 29204 USA.ORCID 0000-0001-6778-4821
Samaneh MatooDepartment of Biological Sciences, University of South Carolina; Columbia, SC 29204 USA.
Jordan A HeadenDepartment of Biological Sciences, University of South Carolina; Columbia, SC 29204 USA.ORCID 0000-0002-8099-4660
Marie-Claire HonoreeDepartment of Biological Sciences, University of South Carolina; Columbia, SC 29204 USA.
Molly ConwayDepartment of Biological Sciences, University of South Carolina; Columbia, SC 29204 USA.ORCID 0009-0004-9939-8211
Lillian F ThompsonDepartment of Chemistry & Biochemistry, University of Virginia; Charlottesville, VA 22904 USA.ORCID 0009-0003-4706-3471
Terika P SmithDepartment of Biological Sciences, University of South Carolina; Columbia, SC 29204 USA.ORCID 0000-0002-1058-0753
Ansley McKayDepartment of Biological Sciences, University of South Carolina; Columbia, SC 29204 USA.ORCID 0009-0003-1991-6203
Cailyn TosadoriDepartment of Biological Sciences, University of South Carolina; Columbia, SC 29204 USA.
Irene Dalla CostaDepartment of Biological Sciences, University of South Carolina; Columbia, SC 29204 USA.ORCID 0000-0002-0924-383X
Moira Lopez De LeonDepartment of Biological Sciences, University of South Carolina; Columbia, SC 29204 USA.
Elizabeth ThamesDepartment of Biological Sciences, University of South Carolina; Columbia, SC 29204 USA.ORCID 0000-0003-0120-7241
Nora Perrone-BizzozeroDepartment of Neurosciences, University of New Mexico; Albuquerque, NM 87131 USA.ORCID 0000-0002-7608-1332
Ashley L KalinskiDepartment of Biological Sciences, University of South Carolina; Columbia, SC 29204 USA.ORCID 0000-0001-7611-0810
Kristy WelshhansDepartment of Biological Sciences, University of South Carolina; Columbia, SC 29204 USA.ORCID 0000-0001-6624-4719
Lauren S VaughnDepartment of Biological Sciences, University of South Carolina; Columbia, SC 29204 USA.ORCID 0000-0003-2282-6738
Jeffery L TwissDepartment of Biological Sciences, University of South Carolina; Columbia, SC 29204 USA.ORCID 0000-0001-7875-6682

Funding

Role of Stress Granule Protein Aggregation in Axon RegenerationR01NS117821 · NINDS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI TWISS, JEFFERY L · 2020 to 2024
$2.8M
Regulating axon guidance through local translation at adhesionsR01NS125146 · NINDS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI Kristy Welshhans · 2023 to 2026
$1.6M
NINDS NIH HHS R01 NS117821NINDS NIH HHS R01 NS125146
6 · The paper itself

Abstract

Injured axons synthesize the RNA Binding Protein KHSRP that promotes mRNA decay and slows nerve regeneration. Axotomy-induced increase in axoplasmic Ca

Indexed as

AxonsNerve RegenerationProtein BiosynthesisAnimalsAxotomyCalciumGrowth ConesPancreatitis-Associated ProteinsRNA-Binding ProteinsRNA, MessengerSciatic NerveCalciumPancreatitis-Associated ProteinsRNA-Binding ProteinsRNA, Messenger

Identifiers

PMID42647628
PMCPMC13510589

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.