Activation of G

Srinivas Pittala, Liu Liu, Dhanush Haspula, Yinghong Cui, Gianluca Fulgenzi, Asuka Inoue, Jürgen Wess

Abstract read

In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Srinivas PittalaMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.ORCID 0000-0002-8873-1320

Liu LiuMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.ORCID 0000-0002-8751-7103

Dhanush HaspulaMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.ORCID 0000-0003-2096-6163

Yinghong CuiMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.ORCID 0000-0002-9889-6655

Gianluca FulgenziDepartment of Clinical and Molecular Sciences (DISCLIMO), Polytechnic University of Marche, Ancona, Italy.ORCID 0000-0003-2646-7728

Asuka InoueGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.ORCID 0000-0003-0805-4049

Jürgen WessMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.ORCID 0000-0003-0818-1232

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impaired insulin secretion represents a key feature of type 2 diabetes (T2D), a major global health burden. Insulin release from pancreatic β cells is regulated by G protein-coupled receptors linked to different functional classes of G proteins. The potential metabolic role of β cell G

Indexed as

Diabetes Mellitus, Type 2GlucoseGTP-Binding Protein alpha Subunits, G12-G13HomeostasisInsulin-Secreting CellsAnimalsInsulinInsulin SecretionMiceMice, KnockoutReceptors, G-Protein-CoupledSignal TransductionGlucoseGTP-Binding Protein alpha Subunits, G12-G13InsulinReceptors, G-Protein-Coupled

Identifiers

PMID42647625

DOI10.1126/sciadv.aeh5504

PMCPMC13510663

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.