Evidence map›Paper›PMID 42647617›Full record

ArticleScience advances2026

Loss of the mitochondrial SAM transporter reveals a lipoylation-dependent metabolic vulnerability in the postnatal heart.

Anastasia Rumyantseva, Trevor S Tippetts, Alissa Wilhalm, William Carter, Marco Moedas, Florian A Rosenberger, David Moore, Ákos Végvári, Yvonne Hinze, Linden Muellner-Wong and 11 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Anastasia RumyantsevaDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 76 Stockholm, Sweden.ORCID 0000-0002-7847-6178
Trevor S TippettsChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-1419-7057
Alissa WilhalmDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 76 Stockholm, Sweden.
William CarterDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 76 Stockholm, Sweden.ORCID 0009-0007-5490-6499
Marco MoedasDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 76 Stockholm, Sweden.ORCID 0000-0001-5461-0320
Florian A RosenbergerDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 76 Stockholm, Sweden.ORCID 0000-0003-4604-6170
David MooreDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 76 Stockholm, Sweden.
Ákos VégváriDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 76 Stockholm, Sweden.ORCID 0000-0002-1287-0906
Yvonne HinzeMax-Planck Institute for Biology of Ageing, 50931 Cologne, Germany.ORCID 0009-0004-5027-0938
Linden Muellner-WongDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 76 Stockholm, Sweden.ORCID 0000-0003-0348-6408
David AlsinaDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 76 Stockholm, Sweden.ORCID 0000-0003-0708-7391
Rolf WibomDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 76 Stockholm, Sweden.ORCID 0000-0001-6721-4642
Rainah WinstonChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Thomas P MathewsChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-9355-8243
Lars H LundDepartment of Medicine, Karolinska Institutet, 171 65 Stockholm, Sweden.ORCID 0000-0003-1411-4482
Daniel C AnderssonCardiology Unit; Heart, Vascular, and Neuro Theme, Karolinska University Hospital, 171 76 Stockholm, Sweden.ORCID 0000-0003-4548-702X
Gianluigi PirontiCardiology Unit; Heart, Vascular, and Neuro Theme, Karolinska University Hospital, 171 76 Stockholm, Sweden.ORCID 0000-0001-9401-3029
Anna WedellCentre for Inherited Metabolic Diseases, Karolinska University Hospital, 171 76 Stockholm, Sweden.ORCID 0000-0002-2612-6301
Ralph J DeBerardinisChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-2705-7432
Christoph FreyerDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 76 Stockholm, Sweden.ORCID 0000-0003-0418-1673
Anna WredenbergDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 76 Stockholm, Sweden.ORCID 0000-0002-2500-6121

Funding

Metabolic Regulators of Tumor Growth and ProgressionR35CA220449 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI RALPH J DEBERARDINIS · 2017 to 2026
$9.4M
Using defective lipoylation as a window into cardiac fuel consumption and failure.F32HL174084 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Trevor Stanley Tippetts · 2024 to 2026
$243k
NCI NIH HHS R35 CA220449NHLBI NIH HHS F32 HL174084
6 · The paper itself

Abstract

The neonatal heart experiences rapid metabolic growth after birth to meet increasing energetic and biosynthetic demands. How mitochondrial cofactor availability limits this transition remains unclear. Here, we demonstrate that mitochondrial

Indexed as

LipoylationMitochondriaMitochondria, HeartMitochondrial ProteinsMyocardiumS-AdenosylmethionineAnimalsAnimals, NewbornMiceMyocytes, CardiacMitochondrial ProteinsS-Adenosylmethionine

Identifiers

PMID42647617
PMCPMC13510680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.