ArticleScience advances2026
A pro-natural product design strategy affords ester-based green fungicide candidates.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Natural products (NPs) serve as both inspirations and resources for the discovery of bioactive compounds. However, their application in green agrochemical discovery faces limitations such as low activity, short duration of efficacy, potential toxicity and residue issues from structural modifications, and constraints in exploring chemical and biological space. Here, we propose the concept and design principles of pro-natural products (PrNPs), which effectively address these limitations and open a broad avenue for bioactive compound discovery. PrNPs are functional compounds designed to degrade into NPs under application conditions. Using this strategy, we designed and synthesized a structurally diverse ester-based PrNP collection with 170 members by combining natural acids and alcohols and found a promising green fungicide candidate, PrNP
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