Evidence map›Paper›PMID 42647600›Full record

ArticleScience translational medicine2026

Urogenital immune signatures are associated with birth outcomes after maternal urinary tract infection.

Samantha Ottinger, Addison B Larson, Vicki Mercado-Evans, Holly Branthoover, Jacob J Zulk, Camille Serchejian, Libbie Ogilvie, Marlyd E Mejia, Zainab A Hameed, Ryan Walde and 4 more

Abstract read
In one paragraph

Article in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Samantha OttingerDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-3439-6376
Addison B LarsonDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Vicki Mercado-EvansDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-9421-9131
Holly BranthooverDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-7808-1662
Jacob J ZulkDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-3758-5503
Camille SerchejianDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Libbie OgilvieDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Marlyd E MejiaDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-4929-6450
Zainab A HameedDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0009-0001-7173-9510
Ryan WaldeDepartment of Pathology, University of South Alabama, Mobile, AL, USA.ORCID 0009-0008-1935-039X
Rachel C FleckDepartment of Microbiology and Immunology, University of South Alabama, Mobile, AL, USA.ORCID 0009-0009-2228-9515
Christopher S WardDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-3445-6327
Allyson E SheaDepartment of Microbiology and Immunology, University of South Alabama, Mobile, AL, USA.ORCID 0000-0003-1329-3888
Kathryn A PatrasDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-2631-8810

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
UM1HG006348: Cas9 Genome Integrity Supplemental ProposalUM1HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI Jason D. Heaney, Chih-Wei Logan Hsu · 2016 to 2026
$47.5M
Organoid Cultivation CoreU19AI157981 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BRITTON, ROBERT A · 2021 to 2025
$12.4M
YEARS 19 - 23: BCM POST-BACCALAUREATE RESEARCH EDUCATION PROGRAMR25GM069234 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PEREIRA, FRED A · 2003 to 2024
$7.5M
Contribution of immune modulation, metabolism, and microbiota to Group B Streptococcal urinary tract infectionR01DK128053 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI PATRAS, KATY · 2021 to 2025
$2.3M
Training Core: Houston Area Incubator for Kidney, Urologic and Hematologic Research Training (HAIKUH)TL1DK147564 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI MARGARET A. GOODELL · 2025 to 2026
$1.8M
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
Vevo 3100 Ultrasound SystemS10OD032380 · OD · BAYLOR COLLEGE OF MEDICINE · PI WARD, CHRISTOPHER S · 2022 to 2022
$312k
Characterizing the Impact of Gestational Diabetes on Immunity and Group B Streptococcal Virulence in the Maternal Reproductive TractF31AI167547 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MERCADO, VICKI · 2022 to 2025
$178k
Characterizing the impact of maternal immune response to urinary tract infection on preterm birthF31HD111236 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI OTTINGER, SAMANTHA · 2023 to 2025
$149k
Determining the role of the vaginal microbiota in microbial and immunological resistance to vaginal pathobiont colonizationF31AI167538 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MEJIA, MARLYD ELIZABETH · 2022 to 2024
$143k
Investigating the influence of human milk oligosaccharides on bacterial-immune dynamics in the gravid vaginal tractF31HD117458 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Holly Branthoover · 2025 to 2026
$100k
NCI NIH HHS P30 CA125123NCRR NIH HHS S10 RR024574NHGRI NIH HHS UM1 HG006348NIAID NIH HHS F31 AI167538NIAID NIH HHS F31 AI167547NIAID NIH HHS U19 AI157981NICHD NIH HHS F31 HD111236NICHD NIH HHS F31 HD117458NIDDK NIH HHS F31 DK136201NIDDK NIH HHS R01 DK128053NIDDK NIH HHS TL1 DK147564NIGMS NIH HHS R25 GM069234NIH HHS S10 OD032380
6 · The paper itself

Abstract

Preterm birth is the leading cause of infant mortality, resulting in more than 1 million neonatal deaths globally each year. Maternal urinary tract infection (UTI) during pregnancy increases risk for preterm birth; however, biological processes mediating UTI-associated preterm birth are not well described. We established a murine maternal UTI model in which challenge with uropathogenic

Indexed as

Pregnancy Complications, InfectiousPregnancy OutcomeUrinary Tract InfectionsAnimalsCytokinesFemaleHumansInterleukin-10MaleMiceMice, Inbred C57BLPregnancyPremature BirthTh17 CellsUropathogenic Escherichia coliCytokinesInterleukin-10

Identifiers

PMID42647600
PMCPMC13621392

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.