Evidence map›Paper›PMID 42647585›Full record

ArticlePLoS biology2026

Behavioral engagement and stimulus regularities coordinate auditory-prefrontal network activity.

Haoxuan Xu, Peirun Song, Hangting Ye, Ana Belén Lao-Rodríguez, Qichen Zhang, Yuying Zhai, Xuehui Bao, Ishrat Mehmood, Hisashi Tanigawa, Zhiyi Tu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Haoxuan XuDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Peirun SongDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Hangting YeDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Ana Belén Lao-RodríguezCognitive and Auditory Neuroscience Laboratory (CANELAB), Institute of Neuroscience of Castilla y León (INCYL), University of Salamanca, Salamanca, Spain.
Qichen ZhangDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yuying ZhaiDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Xuehui BaoCollege of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.
Ishrat MehmoodCollege of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.
Hisashi TanigawaCollege of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.
Zhiyi TuDepartment of Anesthesiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Lingling ZhangDepartment of Anesthesiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Xuan ZhaoDepartment of Anesthesiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
David Pérez-GonzálezCognitive and Auditory Neuroscience Laboratory (CANELAB), Institute of Neuroscience of Castilla y León (INCYL), University of Salamanca, Salamanca, Spain.
Manuel S MalmiercaCognitive and Auditory Neuroscience Laboratory (CANELAB), Institute of Neuroscience of Castilla y León (INCYL), University of Salamanca, Salamanca, Spain.ORCID https://orcid.org/0000-0003-0168-7572
Xiongjie YuDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0000-0002-0040-2187

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability to detect deviations from expected sensory input is fundamental for adaptive behavior. We recorded electrocorticographic activity from the auditory (AC) and prefrontal (PFC) cortices of behaving macaques during an auditory oddball task to probe the cortical dynamics of predictive processing. Repetition of standard stimuli evoked suppression and facilitation in AC and strong low-frequency (2 Hz) enhancement in PFC, accompanied by bidirectional delta-band GC-defined interactions indicative of a shared predictive state. Deviant stimuli triggered earlier AC responses followed by PFC activation and increased GC-defined directed interactions across theta, alpha, and conventional gamma bands. Behavioral engagement amplified both repetition-related and deviance-related ECoG responses, strengthening cortical network coordination. Together, these findings reveal behaviorally gated auditory-prefrontal dynamics that are consistent with hierarchical predictive-processing accounts, while also allowing for contributions from repetition-, novelty-, and salience-related mechanisms.

Indexed as

Auditory CortexAuditory PerceptionBehavior, AnimalPrefrontal CortexAcoustic StimulationAnimalsElectrocorticographyEvoked Potentials, AuditoryMacaca mulattaMaleNerve Net

Identifiers

PMID42647585
PMCPMC13537682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.