ArticleEuropean burn journal2026
Severe Burn Injury Alters Expression of Adrenergic Receptor Transcripts in a Rodent Model.
Article in European burn journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundNorepinephrine is commonly used during acute burn resuscitation to maintain adequate perfusion pressure. However, its effects, together with the burn-induced catecholamine surge, on arterial α
methodsSprague-Dawley rats were randomized to full-thickness scald burn involving 25% total body surface area with continuous intravenous norepinephrine or sodium chloride (NaCl) infusion, sham injury with norepinephrine infusion, or untreated controls. Mean arterial pressure (MAP) was measured at baseline and before euthanasia (six or 24 h). Aorta, carotid, and renal arteries were collected for analysis of α
resultsNorepinephrine efficiently increased MAP in sham animals. In burned animals with norepinephrine, MAP increased at six hours (+10.6 mmHg) but fell below baseline at 24 h (-6.4 mmHg). Burned animals given NaCl had persistently lower MAP than those given norepinephrine, at six hours (-19.1 mmHg) and 24 h (-21.1 mmHg). qPCR demonstrated significant downregulation of
conclusionsNorepinephrine increased MAP in both sham and burned animals, confirming the drug's efficacy. Burn injury and sustained norepinephrine exposure were associated with early, vessel-specific alterations in α
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