ArticleEpigenomes2026
Conserved Partial Reprogramming Effects on the Methylome.
Article in Epigenomes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
5 authors.
Funding
Abstract
BACKGROUND/
objectivesAmong the many proposed theories of aging, a growing body of research points to epigenetic alterations, particularly changes in DNA methylation patterns, as key contributors to biological decline. DNA methylation can be targeted and modulated to induce anti-aging and regenerative effects using an emerging therapeutic approach known as partial reprogramming, induced by different combinations of Yamanaka factors.
methodsIn this study, we performed an integrative secondary analysis of five publicly available DNA methylation datasets derived from partial reprogramming experiments across multiple mammalian species, tissues, cell types and combinations of transcription factors (
resultsFollowing differential methylation analysis of 929,009 CpGs, we identified 14 CpG sites showing reproducible and significant changes, with two CpGs consistently present across all datasets.
conclusionsThese findings suggest that partial reprogramming may exert anti-aging and regenerative effects, in part, through the selective modulation of conserved DNA methylation sites.
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