ArticleCartilage2026
Single-Cell Transcriptomic Profiling Reveals Superficial Zone Chondrocytes as a Catabolic and Senescent Focus in Osteoarthritis Cartilage.
Article in Cartilage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
ObjectiveTo compare zone-specific expression patterns of catabolic proteases and senescence-related genes across chondrocyte subpopulations in osteoarthritis (OA) cartilage.DesignSingle-cell RNA sequencing data from 72,616 chondrocytes (11 human cartilage samples; 6 normal, 5 OA; GSE220243) were analyzed. Following quality control and Harmony-based batch correction, cells were clustered into 27 subpopulations and assigned to superficial (SZ), middle (MZ), deep (DZ), or calcified (CZ) zones using zone-specific gene set module scores. Developmental origin scoring, catabolic gene expression ranking, senescence scoring, and signaling pathway analysis were performed across all clusters.ResultsUpon zonal assignment, the MZ constituted the largest compartment (73.6%), followed by the SZ (21.9%) and CZ (4.5%), with no cluster assigned a dominant DZ identity. MMP13 and ADAMTS5 showed their highest per-cell expression in SZ clusters, with MMP13 most prominent in a FibroC-COL1A2
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