ArticleJournal of medical Internet research2026
Incremental Diagnostic Value of Clinical Information for Large Language Models Across Multiple Organs: Retrospective Study.
Article in Journal of medical Internet research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Background: Although large language models (LLMs) have demonstrated the ability to generate the impression section from radiology findings automatically, the incremental diagnostic value of clinical information for these models remains unclear. Objective: This study aimed to evaluate the incremental diagnostic value of clinical information for LLMs and compare their performance with that of radiologists. Methods: This retrospective study included radiology reports from patients with histopathologically confirmed liver, lung, and breast diseases from 2 institutions between October 2021 and February 2025. We defined three progressive information input scenarios: (1) basic patient information and imaging findings, (2) scenario A plus chief complaint or clinical history, and (3) scenario B plus key laboratory results. Scenario-based data were input into 3 general-purpose LLMs (DeepSeek-R1, Gemini 2.5 Pro, and GPT-4o), generating 2709 entries. Diagnostic accuracy was assessed for both benign-malignant differentiation and disease diagnosis, with histopathology serving as the reference standard. Accuracy was compared among scenarios and against radiologist performance using the McNemar test, and Results: A total of 301 patients with pathologically confirmed diseases were included (mean age 53.5, SD 12.0 years; women: n=208, 69.1%). In the liver cohort, a numerical trend toward higher accuracy was observed in scenario C compared with scenario A across all 3 models (scenario C range: 72.3%-76.2% vs scenario A range: 64.4%-68.3%); these differences did not reach statistical significance after Holm-Bonferroni correction (all adjusted Conclusions: While the addition of clinical information was associated with a numeric trend toward higher diagnostic accuracy overall, this trend was heterogeneous across models and disease types, and no statistically significant improvement was demonstrated after adjustment for multiple comparisons.
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