Evidence map›Paper›PMID 42647061›Full record

ArticleChemMedChem2026

Investigating the Binding Mode of a Naphthol-Based Inhibitor Targeting SARS-CoV-2 Main Protease.

Ifigeneia Akrani, Haifa El Kilani, Franck Touret, Sophia Kouvali, Veronika Gourni, Aggeliki Tsoka, Joulia K Tsetis, Constantinos Vorgias, Rolf Hilgenfeld, Ioannis K Kostakis and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ifigeneia AkraniDepartment of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0009-0006-6260-4493
Haifa El KilaniInstitute of Molecular Medicine, University of Lübeck, Lübeck, Germany.
Franck TouretUnité des Virus Émergents (UVE: Aix-Marseille Univ, Università di Corsica, Institution IRD 190, Inserm 1207, RBA), Marseille, France.ORCID https://orcid.org/0000-0002-4734-2249
Sophia KouvaliDepartment of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
Veronika GourniDepartment of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
Aggeliki TsokaDepartment of Biology, National and Kapodistrian University of Athens, Athens, Greece.
Joulia K TsetisUni-Pharma S.A., Athens, Greece.
Constantinos VorgiasDepartment of Biology, National and Kapodistrian University of Athens, Athens, Greece.
Rolf HilgenfeldInstitute of Molecular Medicine, University of Lübeck, Lübeck, Germany.
Ioannis K KostakisDepartment of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0002-9901-5223
Vassilios MyrianthopoulosDepartment of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0001-8359-9634
Emmanuel MikrosDepartment of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0002-5984-5169

Funding

HORIZON-MSCA-2022-SE-01 "GreenCosmIn" Project 101131346"KLEON TSETIS Non-Profit Civil Company (NPCC) for Scientific Research and Culture" (KLEON TSETIS Foundation) 22476
6 · The paper itself

Abstract

Regardless of the massive global efforts to combat the virus causing SARS-CoV-2 syndrome, the infection remains a substantial health challenge worldwide in the years following 2019. To this direction, targeting the main viral protease M

Indexed as

Antiviral AgentsBetacoronavirusCoronavirus 3C ProteasesNaphtholsProtease InhibitorsSARS-CoV-2Viral Nonstructural ProteinsAnimalsBinding SitesCrystallography, X-RayHumansProtein BindingStructure-Activity RelationshipThermodynamics3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesNaphtholsProtease InhibitorsViral Nonstructural Proteinsantiviral agentsbiophysicsconsensus screeningmolecular simulationsnaphthols

Identifiers

PMID42647061
PMCPMC13512774

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.