Evidence map›Paper›PMID 42646988›Full record

ArticleToxics2026

Aqueous Extract of Saposhnikoviae Radix Antagonizes Arsenic Neurotoxicity via the NLRP3/Caspase-1/GSDMD Pyroptotic Axis: Translating Environmental Exposure into Neuropathology and Herbal Recalibration.

Xiao-Ping Zeng, Yu Liu, Bin He, Ji-Gang Pan

Abstract read
In one paragraph

Article in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiao-Ping ZengKey Laboratory for Basic and Clinical Research of Cardiovascular Diseases, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Guizhou Medical University, Guian New Area, Guiyang 561113, China.
Yu LiuKey Laboratory for Basic and Clinical Research of Cardiovascular Diseases, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Guizhou Medical University, Guian New Area, Guiyang 561113, China.
Bin HeState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, School of Pharmacy, Guizhou Medical University, Guian New Area, Guiyang 561113, China.
Ji-Gang PanKey Laboratory for Basic and Clinical Research of Cardiovascular Diseases, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Guizhou Medical University, Guian New Area, Guiyang 561113, China.ORCID 0000-0001-7947-8426

Funding

Guiyang Medical University No. 2024001Guizhou Provincial Science and Technology Department GCC[2022] 030-2Guizhou Provincial Science and Technology Department ZK[2022]035Health Commission of Guizhou Province gzwkj2021-532
6 · The paper itself

Abstract

Chronic arsenic exposure causes neurological damage, but the underlying mechanisms remain incompletely understood. This study investigated whether Saposhnikoviae Radix (SR) aqueous extract protects against arsenic-induced neurotoxicity by modulating pyroptosis. Kunming mice were exposed to NaAsO

Indexed as

anxiety-like behaviorcognitive impairmentenvironmental neurotoxicantneuroexposomeneuroinflammationtraditional Chinese medicine

Identifiers

PMID42646988
PMCPMC13517699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.