Evidence map›Paper›PMID 42646982›Full record

ArticleToxics2026

Acute Toxic Impact of Cyclophosphamide on the Metabolic Organs of Siamese Fighting Fish (

Somkiat Sreebun, Sukumal Prukudom, Kannika Siripattarapravat, Supreeya Srisampan, Aksorn Saengtienchai, Piyaporn Eiamcharoen, Santi Poungcharean, Chonphoom Phanpoe, Onanong Suksao, Usuma Jermnak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Somkiat SreebunGraduate Program in Animal Health and Biomedical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
Sukumal PrukudomDepartment of Anatomy, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.ORCID 0000-0002-2001-136X
Kannika SiripattarapravatDepartment of Pathology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.ORCID 0000-0002-5847-2356
Supreeya SrisampanCenter for Veterinary Diagnostic Laboratory, Bangkhen, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
Aksorn SaengtienchaiDepartment of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
Piyaporn EiamcharoenDepartment of Pathology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.ORCID 0000-0002-1947-9889
Santi PoungchareanDepartment of Fishery Biology, Faculty of Fisheries, Kasetsart University, Bangkok 10900, Thailand.ORCID 0000-0002-8521-4897
Chonphoom PhanpoeCenter for Veterinary Diagnostic Laboratory, Bangkhen, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
Onanong SuksaoNakhon Pathom Provincial Public Health Office, Nakhon Pathom 73000, Thailand.
Usuma JermnakDepartment of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.ORCID 0009-0005-0886-0026

Funding

the Kasetsart Veterinary Development Fund of the Faculty of Veterinary Medicine, Kasetsart University
6 · The paper itself

Abstract

Currently, emerging pharmaceutical contaminants (EPCs) pose a significant risk to aquatic biodiversity on both a global and regional scale. Their accumulation in the environment presents several challenges to both human health and ecological integrity. Among EPCs, cyclophosphamide (COP), a widely used alkylating cytotoxic and immunosuppressive drug in human and veterinary oncology, has become one of the most frequently detected environmental contaminants. It has been reported to impair the immune system, induce oxidative stress, and exhibit genotoxic and cytotoxic effects in various fish species. However, limited research has evaluated its toxicity in the Siamese fighting fish (

Indexed as

acute toxicityBetta splendenscyclophosphamideemerging pharmaceutical contaminantskidneyliveroxidative stressSiamese fighting fish

Identifiers

PMID42646982
PMCPMC13517365

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.