ArticleToxics2026
Pulmonary Toxicity and Biodistribution of Sodium Fluoride in Male Rats Following Intratracheal Instillation and Nose-Only Inhalation Exposure.
Article in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
Pulmonary exposure to sodium fluoride (NaF) may occur in certain consumer-product and occupational settings, but its pulmonary toxicity and systemic biodistribution remain insufficiently characterized. This study investigated acute pulmonary inflammatory responses and biodistribution kinetics in rats following a single airway exposure to NaF. Non-radioactive NaF was administered in 7-week-old male Sprague-Dawley rats by intratracheal instillation at 0.75, 1.5, or 3.0 mg/rat, and pulmonary responses were evaluated at 1, 7, and 28 days using bronchoalveolar lavage fluid analysis and histopathology. Biodistribution was assessed using positron emission tomography/computed tomography (PET/CT) and organ gamma counting after administration of fluorine-18 radiolabeled sodium fluoride ([
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