Long-Term Oral Exposure to Chlorophenylacetonitrile Induces Gastrointestinal Morphological Alterations and Splenic Transcriptomic Reprogramming in Mice.

Yayun Zhang, Fei Liu, Hao Zhou, Jingwen Chen, Lei Jiang, Changchun Yan, Xiaodong Li, Dingming Xue, Jiangfei Wang

Abstract read

In one paragraph

Article in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Yayun ZhangState Key Laboratory of Water Pollution Control and Green Resource Recycling, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.

Fei LiuKey Laboratory of Lake and Watershed Science for Water Security, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210008, China.

Hao ZhouNanjing Institute of Environmental Sciences, Ministry of Ecology and Environment, No.8 Jiangwangmiao Street, Nanjing 210042, China.ORCID 0000-0003-2038-6572

Jingwen ChenInstitute of Agricultural Facilities and Equipment, Jiangsu Academy of Agricultural Sciences, Jiangsu Engineering Technology Research Center of Biomass Composites and Addictive Manufacturing, Key Laboratory for Protected Agricultural Engineering in the Middle and Lower Reaches of Yangtze River, Ministry of Agriculture and Rural Affairs, Nanjing 210014, China.

Lei JiangNanjing Institute of Environmental Sciences, Ministry of Ecology and Environment, No.8 Jiangwangmiao Street, Nanjing 210042, China.

Changchun YanNanjing Institute of Environmental Sciences, Ministry of Ecology and Environment, No.8 Jiangwangmiao Street, Nanjing 210042, China.

Xiaodong LiNanjing Institute of Environmental Sciences, Ministry of Ecology and Environment, No.8 Jiangwangmiao Street, Nanjing 210042, China.ORCID 0000-0001-8484-6318

Dingming XueNanjing Institute of Environmental Sciences, Ministry of Ecology and Environment, No.8 Jiangwangmiao Street, Nanjing 210042, China.ORCID 0000-0002-8380-7859

Jiangfei WangEcological and Environmental Monitoring Center of Zhejiang Province, Hangzhou 310012, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chlorophenylacetonitriles are known as one of the emerging nitrogenous disinfection byproducts (N-DBPs) in chlorinated drinking water due to their concerned cytotoxicity and genotoxicity compared to regulated carbonaceous DBPs. However, under low-dose exposure, the in vivo pathological consequences of chlorophenylacetonitriles remain largely unresolved. Here, C57BL/6J mice were exposed to 2-chlorophenylacetonitrile (2-CPAN) via drinking water (100 ug/L) for six months, and an integrated histopathological and genome-wide transcriptomic approach was employed to mechanistically characterize its multi-organ toxicological consequences. 2-CPAN ingestion significantly suppressed body weight (35.9 ± 2.0 g vs. 47.6 ± 11.6 g,

Indexed as

2-chlorophenylacetonitrilecell cycle arrestepithelial barrier failuregut–spleen axisimmunotoxicitynitrogenous disinfection byproducts

Identifiers

PMID42646930

DOI10.3390/toxics14080647

PMCPMC13517901

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.