Optical Quality Degradation Following Nd:YAG Laser-Induced Intraocular Lens Pitting: A Multimodal Experimental Study.

Nd laser posterior capsulotomy is the standard treatment for posterior capsule opacification following cataract surgery. Although generally considered safe, inadvertent laser impacts on the intraocular lens (IOL) optic may induce permanent surface defects that contribute to postoperative dysphotopsias and reduced visual quality. This experimental study investigated the optical consequences of Nd laser-induced damage on two commercially available hydrophobic acrylic IOLs, focusing on retinal light distribution and optical image quality. Two hydrophobic acrylic monofocal IOL models, the CT LUCIA (Carl Zeiss Meditec) and the AcrySof IQ (Alcon), were mounted on a customized experimental holder and exposed to standardized Nd laser applications consisting of 5, 10, or 15 laser shots. Laser interactions were documented using the PhysioGo.Lite laser platform combined with infrared thermal imaging. Untreated IOLs served as controls. Optical performance was subsequently evaluated using a standardized optical bench according to ISO recommendations. Point spread function (PSF) and modulation transfer function (MTF) analyses were performed to quantify retinal image quality, light scattering, and optical degradation. Retinal light distribution was assessed using a high-resolution projection screen simulating the retinal image. Laser exposure produced permanent focal defects on the anterior optical surface of both IOL models, resulting in measurable optical degradation. Even the lowest laser exposure (five shots) generated detectable alterations in light propagation, characterized by increased peripheral light scattering, enlargement of the PSF halo, reduced central peak intensity, and irregular light distribution across the simulated retinal plane. Descriptively, increasing numbers of laser impacts were associated with more pronounced optical disturbances, particularly in the AcrySof IQ samples. MTF analysis demonstrated a reduction in optical performance across multiple spatial frequencies, indicating deterioration of image contrast and resolving power. Although both hydrophobic acrylic IOL models exhibited optical alterations after laser exposure, descriptive differences in the magnitude and distribution of light scatter suggested a possible influence of material composition, refractive index, and surface microarchitecture. These observations should be considered preliminary because of the limited sample size and absence of inferential statistical analysis. Under the present experimental conditions, Nd:YAG laser-induced pitting was associated with measurable structural and optical alterations in two hydrophobic acrylic IOL models. Surface defects alter retinal light distribution, increase forward light scatter, and reduce optical quality, providing a possible optical mechanism that may contribute to postoperative dysphotopsias, although clinical visual symptoms were not directly evaluated in this study. These findings highlight the importance of meticulous laser focusing on the posterior capsule to minimize inadvertent IOL damage and preserve postoperative visual quality. Further investigations combining optical bench analyses with patient-reported visual outcomes are warranted to better define the clinical significance of laser-induced IOL pitting.