S-Methylmethionine Attenuates Aflatoxin B1-Induced Mammary Epithelial Injury: Functional Assessment and Exploratory ATAC-Seq/RNA-Seq Analysis.

Jin Huang, Chenxi Ling, Yuxuan Li, Yake Wang, Liyu Yang, Qiuliang Xu, Hongyu Deng, Congcong Li

Abstract read

In one paragraph

Article in Toxins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jin HuangCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.ORCID 0000-0002-7635-9787

Chenxi LingCollege of Animal Sciences, Xinjiang Agricultural University, Urumqi 830052, China.

Yuxuan LiCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.

Yake WangCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.

Liyu YangCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.

Qiuliang XuCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.

Hongyu DengCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.

Congcong LiCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.ORCID 0000-0002-0914-8955

Funding

Joint Funds of the National Natural Science Foundation of China U2004156Key Project of International Science and Technology Cooperation in Henan Province 251111520200Open Project of Key Laboratory of Innovative Utilization of Unconventional Feed Resources in Henan Province FCG-2023-08Program for Cultivating Young Backbone Teachers in Higher Education Institutions in Henan Province 2024GGJS152

6 · The paper itself

Abstract

Aflatoxin 1. (AFB1) threatens animal health and dairy safety, but mammary-protective interventions remain poorly defined. We evaluated whether S-methylmethionine (SMM; commonly known as vitamin U) attenuates AFB1-associated injury using MAC-T bovine mammary epithelial cells, a mouse mammary model, biochemical assays, RT-qPCR, Western blotting, H&E staining, and exploratory ATAC-seq/RNA-seq analysis. Under 4 μg/mL (approximately 12.81 μM) AFB1 challenge, 1 mM SMM increased MAC-T cell viability by 14.1% (Tukey-adjusted

Indexed as

Aflatoxin B1Epithelial CellsMammary Glands, AnimalAnimalsCattleCell LineCell SurvivalFemaleMiceNF-E2-Related Factor 2Oxidative StressRNA-SeqAflatoxin B1NF-E2-Related Factor 2aflatoxin B1ATAC-seq/RNA-seqmammary epithelial cellsoxidative stressS-methylmethionine

Identifiers

PMID42646772

DOI10.3390/toxins18080344

PMCPMC13517378

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.