Evidence map›Paper›PMID 42646765›Full record

ArticleToxins2026

Apurva Lad, Mudit Bhatia, Johnna A Birbeck, Alex Kuang, Elliot Furr, Judy Westrick, Youngwoo Seo, Dae-Wook Kang, David J Kennedy, Steven T Haller

Abstract read
In one paragraph

Article in Toxins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Apurva LadDepartment of Medicine, University of Toledo, Mail Stop 1040, Health Education Building, Toledo, OH 43614, USA.ORCID 0000-0001-6073-7432
Mudit BhatiaDepartment of Civil and Environmental Engineering, University of Toledo, Mail Stop 307, 3006 Nitschke Hall, Toledo, OH 43606, USA.ORCID 0000-0001-7246-6625
Johnna A BirbeckLumigen Instrument Center, Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.
Alex KuangLumigen Instrument Center, Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.
Elliot FurrLumigen Instrument Center, Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.
Judy WestrickLumigen Instrument Center, Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.
Youngwoo SeoDepartment of Civil and Environmental Engineering, University of Toledo, Mail Stop 307, 3006 Nitschke Hall, Toledo, OH 43606, USA.
Dae-Wook KangDepartment of Civil and Environmental Engineering, University of Toledo, Mail Stop 307, 3006 Nitschke Hall, Toledo, OH 43606, USA.ORCID 0000-0002-2585-1974
David J KennedyDepartment of Medicine, University of Toledo, Mail Stop 1040, Health Education Building, Toledo, OH 43614, USA.ORCID 0000-0001-5265-0142
Steven T HallerDepartment of Medicine, University of Toledo, Mail Stop 1040, Health Education Building, Toledo, OH 43614, USA.ORCID 0000-0002-6919-6342

Funding

The synergistic effects of climate and anthropogenic drivers on toxic cyanobacterial bloomsP01ES028939 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Gregory James Dick, David Joseph Kennedy · 2018 to 2026
$3.7M
NIEHS NIH HHS P01 ES028939NIH and NSF awards to the Great Lakes Center for Fresh Waters and Human Health NIH: 1P01ES028939-01, NSF: OCE-1840715Ohio Water Development Authority 8675United States Army Corps of Engineers W912HZ2120015
6 · The paper itself

Abstract

Excessive cyanobacterial proliferation and toxin production increasingly threaten freshwater ecosystems, drinking water systems, and public health. Among cyanotoxins, microcystin-LR (MC-LR) is one of the most prevalent variants and is recognized for its hepatotoxicity, with evidence showing it can also alter gut microbiota composition. Previous studies, including our own, demonstrate that MC exposure can induce inflammation, oxidative stress, and changes in gene expression associated with immune responses, even at concentrations below guideline limits. This study investigated the protective effect of an MC-degrading bacterium,

Indexed as

HepatocytesMicrocystinsSphingomonadaceaeCell Line, TumorHumansInflammationMarine ToxinsTransforming Growth Factor beta1Tumor Necrosis Factor-alphacyanoginosin LRMarine ToxinsMicrocystinsTransforming Growth Factor beta1Tumor Necrosis Factor-alphacyanotoxinsharmful algal bloomsHep3B cell linehepatotoxicitymicrocystin-LRprobioticsSphingopyxis sp. IM1

Identifiers

PMID42646765
PMCPMC13517449

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.