Evidence map›Paper›PMID 42646753›Full record

ReviewToxins2026

Anti-Mycotoxin Agents in Pig Production Through the Lens of Circular Economy and Life Cycle Assessment: A Comprehensive Review.

Georgios I Papakonstantinou, Christos Eliopoulos, Dimitrios Arapoglou, Nikolaos Tsekouras, Katerina Manolakou, Labrini V Athanasiou, Dimitrios Gougoulis, Soultanidis Aris, Vasileios G Papatsiros

Abstract readReview
In one paragraph

Review in Toxins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Georgios I PapakonstantinouClinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece.ORCID 0000-0002-3434-0877
Christos EliopoulosInstitute of Technology of Agricultural Products, Hellenic Agricultural Organization-Demeter (HAO-Demeter), 14123 Athens, Greece.ORCID 0000-0003-0702-3718
Dimitrios ArapoglouInstitute of Technology of Agricultural Products, Hellenic Agricultural Organization-Demeter (HAO-Demeter), 14123 Athens, Greece.ORCID 0000-0002-6526-5945
Nikolaos TsekourasClinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece.ORCID 0000-0002-2309-8296
Katerina ManolakouDepartment of Animal Husbandry and Nutrition, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece.
Labrini V AthanasiouClinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece.ORCID 0000-0001-8723-2629
Dimitrios GougoulisClinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece.ORCID 0000-0001-9229-3151
Soultanidis ArisClinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece.
Vasileios G PapatsirosClinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece.ORCID 0000-0003-4955-0460

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mycotoxin contamination of cereal-based pig feeds is a persistent threat to swine health and global pork safety. Pigs are uniquely susceptible to mycotoxicosis, and the principal toxins-aflatoxins (AFs), deoxynivalenol (DON), zearalenone (ZEN), fumonisins (FUMs), and ochratoxin A (OTA)-cause impaired growth, reproductive failure, hepato- and nephrotoxicity, immunosuppression, and carry-over residues in edible tissue. Anti-mycotoxin feed additives, including mineral adsorbents, biotransforming agents, and multicomponent mycotoxin-detoxifying agents (MMDAs) combining clays, phytogenic antioxidants (curcumin, silymarin), and postbiotics (yeast cell wall, hydrolyzed yeast), constitute the primary mitigation strategy. Beyond animal health, these agents play underappreciated roles in both the circular economy (CE)-enabling safe valorization of by-product feed ingredients and reducing feed waste-and in the life cycle assessment (LCA) sustainability profile of pork production, where feed conversion ratio (FCR) drives 22-95% of greenhouse gas emissions. Field-based in vivo studies in sows and weaned piglets, integrating plasma oxidative stress biomarkers (TBARS, protein carbonyls, total antioxidant capacity) with performance and reproductive endpoints, provide the most comprehensive real-world evidence for MMDA efficacy to date. This review synthesizes mycotoxin toxicology, anti-mycotoxin agent mechanisms, clinical evidence, and the CE/LCA sustainability framework, proposing integrated mycotoxin management as a One Health imperative in modern swine production.

Indexed as

Animal FeedFood ContaminationMycotoxinsAnimalsSwineMycotoxinsanti-mycotoxin agentscircular economylife cycle assessmentmulticomponent detoxifiermycotoxinsoxidative stresspigssustainability

Identifiers

PMID42646753
PMCPMC13517686

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.