Evidence map›Paper›PMID 42646718›Full record

ArticleVaccines2026

An In Vitro Screen Identifies H1 Influenza Hemagglutinin Substitutions That Alter mRNA-LNP Vaccine Responses Against the Stalk Domain.

Samuel W Rovito, Po-Ling Chen, Guohua Yang, Haley N Writt, Ashley N Zalla, Marissa A Donofrio, Jonathan N Fogo, Richard J Webby, James D Brien, Charles J Russell

Abstract read
In one paragraph

Article in Vaccines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Samuel W RovitoSt. Jude Graduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0009-0000-3073-8215
Po-Ling ChenDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-7179-6144
Guohua YangDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Haley N WrittDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Ashley N ZallaDepartment of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Marissa A DonofrioDepartment of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40536, USA.ORCID 0009-0007-6732-2310
Jonathan N FogoDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0001-7490-9813
Richard J WebbySt. Jude Graduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-4397-7132
James D BrienDepartment of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Charles J RussellSt. Jude Graduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0001-5683-3990

Funding

COVID Supplement - COMPONENT A OF THE COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) PROGRAM TO DESIGN AND EVALUATE INNOVATIVE INFLUENZA VACCINE APPROACHES,75N93019C00052 · NIAID · UNIVERSITY OF GEORGIA · PI ROSS, TED · 2019 to 2025
$74.6M
National Institute of Allergy and Infectious DiseasesNIH HHS 75N93019C00052
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

antigen engineeringH1N1hemagglutininimmunogenicityinfluenza vaccinemRNA vaccinestalk antibody

Identifiers

PMID42646718
PMCPMC13517961

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.